Adaptive radiotherapy for long course neo-adjuvant treatment of rectal cancer.

Marcel Van Herk; Jasper Nijkamp; Corrie Marijnen; Marcel van Herk; Baukelien van Triest; Jan-Jakob Sonke

doi:10.1016/j.radonc.2012.02.013

Adaptive radiotherapy for long course neo-adjuvant treatment of rectal cancer.

Marcel Van Herk, Jasper Nijkamp, Corrie Marijnen, Marcel van Herk, Baukelien van Triest, Jan-Jakob Sonke

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: To quantify the potential margin reduction with adaptive radiotherapy (ART) during neo-adjuvant treatment of locally-advanced rectal cancer. METHODS AND MATERIALS: Repeat CT scans were acquired for 28 patients treated with 25×2 Gy, daily during the first week, and followed by weekly scans. The CTV was delineated on all scans, and shape variation was estimated. Five ART strategies were tested, consisting of an average CTV over the planning CT and one to five repeat CTs. Required PTV margins were calculated for adapted and non-adapted treatment. The strategy with the least PTV volume over the whole treatment was selected and bowel area dose reduction was estimated. RESULTS: Substantial systematic and random shape variation demanded for a PTV margin up to 2.4 cm at the upper-anterior part of the CTV. Plan adaptation after fraction 4 resulted in a maximum 0.7 cm margin reduction and a significant PTV reduction from 1185 to 1023 cc (p

Original language	English
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2012.02.013
Publication status	Published - Jun 2012

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10.1016/j.radonc.2012.02.013

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@article{31a92c5026684f28ab2d50cce67cd538,

title = "Adaptive radiotherapy for long course neo-adjuvant treatment of rectal cancer.",

abstract = "PURPOSE: To quantify the potential margin reduction with adaptive radiotherapy (ART) during neo-adjuvant treatment of locally-advanced rectal cancer. METHODS AND MATERIALS: Repeat CT scans were acquired for 28 patients treated with 25×2 Gy, daily during the first week, and followed by weekly scans. The CTV was delineated on all scans, and shape variation was estimated. Five ART strategies were tested, consisting of an average CTV over the planning CT and one to five repeat CTs. Required PTV margins were calculated for adapted and non-adapted treatment. The strategy with the least PTV volume over the whole treatment was selected and bowel area dose reduction was estimated. RESULTS: Substantial systematic and random shape variation demanded for a PTV margin up to 2.4 cm at the upper-anterior part of the CTV. Plan adaptation after fraction 4 resulted in a maximum 0.7 cm margin reduction and a significant PTV reduction from 1185 to 1023 cc (p",

author = "{Van Herk}, Marcel and Jasper Nijkamp and Corrie Marijnen and {van Herk}, Marcel and {van Triest}, Baukelien and Jan-Jakob Sonke",

year = "2012",

month = jun,

doi = "10.1016/j.radonc.2012.02.013",

language = "English",

volume = "103",

journal = "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",

issn = "0167-8140",

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TY - JOUR

T1 - Adaptive radiotherapy for long course neo-adjuvant treatment of rectal cancer.

AU - Van Herk, Marcel

AU - Nijkamp, Jasper

AU - Marijnen, Corrie

AU - van Herk, Marcel

AU - van Triest, Baukelien

AU - Sonke, Jan-Jakob

PY - 2012/6

Y1 - 2012/6

N2 - PURPOSE: To quantify the potential margin reduction with adaptive radiotherapy (ART) during neo-adjuvant treatment of locally-advanced rectal cancer. METHODS AND MATERIALS: Repeat CT scans were acquired for 28 patients treated with 25×2 Gy, daily during the first week, and followed by weekly scans. The CTV was delineated on all scans, and shape variation was estimated. Five ART strategies were tested, consisting of an average CTV over the planning CT and one to five repeat CTs. Required PTV margins were calculated for adapted and non-adapted treatment. The strategy with the least PTV volume over the whole treatment was selected and bowel area dose reduction was estimated. RESULTS: Substantial systematic and random shape variation demanded for a PTV margin up to 2.4 cm at the upper-anterior part of the CTV. Plan adaptation after fraction 4 resulted in a maximum 0.7 cm margin reduction and a significant PTV reduction from 1185 to 1023 cc (p

AB - PURPOSE: To quantify the potential margin reduction with adaptive radiotherapy (ART) during neo-adjuvant treatment of locally-advanced rectal cancer. METHODS AND MATERIALS: Repeat CT scans were acquired for 28 patients treated with 25×2 Gy, daily during the first week, and followed by weekly scans. The CTV was delineated on all scans, and shape variation was estimated. Five ART strategies were tested, consisting of an average CTV over the planning CT and one to five repeat CTs. Required PTV margins were calculated for adapted and non-adapted treatment. The strategy with the least PTV volume over the whole treatment was selected and bowel area dose reduction was estimated. RESULTS: Substantial systematic and random shape variation demanded for a PTV margin up to 2.4 cm at the upper-anterior part of the CTV. Plan adaptation after fraction 4 resulted in a maximum 0.7 cm margin reduction and a significant PTV reduction from 1185 to 1023 cc (p

U2 - 10.1016/j.radonc.2012.02.013

DO - 10.1016/j.radonc.2012.02.013

M3 - Article

C2 - 22444244

SN - 0167-8140

VL - 103

JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

IS - 3

ER -

Adaptive radiotherapy for long course neo-adjuvant treatment of rectal cancer.

Abstract

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