Adenosine and ATP receptors in the brain

Geoffrey Burnstock, Bertil B. Fredholm, Alexei Verkhratsky

    Research output: Contribution to journalArticlepeer-review


    There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y receptors largely mediate presynaptic activities. Both P1 and P2 receptors participate in neurone-glia interactions. Purinergic signalling is involved in control of cerebral vascular tone and remodelling. Examples of the roles of purinoceptors in neuropathology involve: A2A receptors in Parkinson's disease and epilepsy, P2 receptors in trauma, ischaemia, neuroinflammatory and neuropsychiatric disorders, and neuropathic pain. © 2011 Bentham Science Publishers Ltd.
    Original languageEnglish
    Pages (from-to)973-1011
    Number of pages38
    JournalCurrent Topics in Medicinal Chemistry
    Issue number8
    Publication statusPublished - 2011


    • CNS
    • Glia
    • Ischaemia
    • Neurodegeneration
    • Neurones
    • Neuropathology
    • Purinergic transmission


    Dive into the research topics of 'Adenosine and ATP receptors in the brain'. Together they form a unique fingerprint.

    Cite this