@article{5618cc0ab2cc408eb8ff6185611a4ac5,
title = "Adenosine triphosphate in exhaled breath condensate of healthy subjects and patients with chronic obstructive pulmonary disease",
abstract = "Objectives: The effect of hypoxic relapse of chronic obstructive pulmonary disease (COPD) on lung adenosine triphosphate (ATP) concentration was studied measuring ATP in exhaled breath condensate (EBC). Subjects: Thirty COPD patients with severe exacerbation, thirteen healthy non-smokers and thirteen healthy smokers. Methods: ATP was detected using a luciferin-luciferase assay, dilution of airway droplets in EBC was assessed measuring sample conductivity. Results: ATP concentrations were similar in COPD patients, non-smoking and smoking healthy individuals (141 ± 44, 115 ± 21 and 90 ± 15 pM; p = 0.66). After treatment oxygenation of COPD patients improved (6.85 ± 1.29 kPa vs 8.20 ± 1.28 kPa, p ",
keywords = "Adenosine triphosphate, Airways, Chronic obstructive pulmonary disease, Exhaled breath condensate, Hypoxia, adenosine triphosphate, luciferase, luciferin, adult, article, chronic obstructive lung disease, clinical article, controlled study, disease exacerbation, disease marker, enzyme assay, exhalation, female, human, hypoxia, male, oxygenation, protein blood level, protein determination, smoking, Adenosine Triphosphate, Adult, Aged, Anoxia, Body Fluids, Breath Tests, Exhalation, Female, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Smoking",
author = "Z. L{\'a}z{\'a}r and {\'E}. Husz{\'a}r and T. Kullmann and I. Barta and B. Antus and A. Bikov and M. Kollai and I. Horv{\'a}th",
note = "Cited By :21 Export Date: 20 February 2019 CODEN: INREF Correspondence Address: Horv{\'a}th, I.; Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, 78/a {\"U}ll{\"o}i Street, Budapest, 1082, Hungary; email: hildiko@elet2.sote.hu Chemicals/CAS: adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; luciferin, 2591-17-5; Adenosine Triphosphate, 56-65-5 Funding details: 68808 Funding details: Canon Foundation for Scientific Research, CFSR, OTKA 43396 Funding text 1: Funding. This study was supported by the Hungarian Scientific Research Foundation (OTKA 43396 and 68808). References: Adriaensen, D., Timmermans, J.P., Purinergic signalling in the lung: Important in asthma and COPD? 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year = "2008",
doi = "10.1007/s00011-008-8009-6",
language = "English",
volume = "57",
pages = "367--373",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkh{\"a}user Verlag Ag",
number = "8",
}
