Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank

Nicola Veronese; Lin Yang; Laura Piccio; Lee Smith; Joseph Firth; Wolfgang Marx; Gianluigi Giannelli; Maria Gabriella Caruso; Anna Maria Cisternino; Maria Notarnicola; Rossella Donghia; Mario Barbagallo; Luigi Fontana

doi:10.1080/1028415X.2020.1846357

Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank

Nicola Veronese
, Lin Yang
, Laura Piccio
, Lee Smith
, Joseph Firth
, Wolfgang Marx
, Gianluigi Giannelli
, Maria Gabriella Caruso
, Anna Maria Cisternino
, Maria Notarnicola
, Rossella Donghia
, Mario Barbagallo
, Luigi Fontana

Division of Psychology & Mental Health (L5)

University of Palermo
Washington University in St Louis
Anglia Ruskin University
Deakin University
National Institute of Gastroenterology-Research Hospital, IRCCS "S. de Bellis"
Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.

OBJECTIVE: To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).

METHODS: By using a case-control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).

RESULTS: 728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0-1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15-0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.

CONCLUSION: Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Nutritional Neuroscience
Early online date	9 Dec 2020
DOIs	https://doi.org/10.1080/1028415X.2020.1846357
Publication status	E-pub ahead of print - 9 Dec 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1080/1028415X.2020.1846357

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Veronese, N., Yang, L., Piccio, L., Smith, L., Firth, J., Marx, W., Giannelli, G., Caruso, M. G., Cisternino, A. M., Notarnicola, M., Donghia, R., Barbagallo, M., & Fontana, L. (2020). Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank. Nutritional Neuroscience, 1-9. Advance online publication. https://doi.org/10.1080/1028415X.2020.1846357

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title = "Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank",

abstract = "BACKGROUND: Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.OBJECTIVE: To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).METHODS: By using a case-control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95\% confidence intervals (CIs).RESULTS: 728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0-1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71\% lower odds of having MS (OR = 0.29; 95\% CI: 0.15-0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.CONCLUSION: Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.",

author = "Nicola Veronese and Lin Yang and Laura Piccio and Lee Smith and Joseph Firth and Wolfgang Marx and Gianluigi Giannelli and Caruso, \{Maria Gabriella\} and Cisternino, \{Anna Maria\} and Maria Notarnicola and Rossella Donghia and Mario Barbagallo and Luigi Fontana",

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doi = "10.1080/1028415X.2020.1846357",

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T1 - Adherence to a healthy lifestyle and multiple sclerosis

T2 - a case-control study from the UK Biobank

AU - Veronese, Nicola

AU - Yang, Lin

AU - Piccio, Laura

AU - Smith, Lee

AU - Firth, Joseph

AU - Marx, Wolfgang

AU - Giannelli, Gianluigi

AU - Caruso, Maria Gabriella

AU - Cisternino, Anna Maria

AU - Notarnicola, Maria

AU - Donghia, Rossella

AU - Barbagallo, Mario

AU - Fontana, Luigi

PY - 2020/12/9

Y1 - 2020/12/9

N2 - BACKGROUND: Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.OBJECTIVE: To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).METHODS: By using a case-control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).RESULTS: 728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0-1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15-0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.CONCLUSION: Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.

AB - BACKGROUND: Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.OBJECTIVE: To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).METHODS: By using a case-control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).RESULTS: 728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0-1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15-0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.CONCLUSION: Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.

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DO - 10.1080/1028415X.2020.1846357

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SN - 1028-415X

SP - 1

EP - 9

JO - Nutritional Neuroscience

JF - Nutritional Neuroscience

ER -

Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank

Abstract

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