Adherence to treatment in Swedish HIV-infected patients

B. Södergård, M. Halvarsson, M. P. Tully, S. Mindouri, M. L. Nordström, S. Lindbäck, A. Sönnerborg, Å K. Lindblad

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives: The objectives were to assess the prevalence of adherence to antiretroviral treatment in Swedish human immunodeficiency virus (HIV)-infected patients and to evaluate factors associated with adherence. Methods: All HIV-treated patients, who attended one of 30 (of a total of 32) Swedish infectious diseases clinics, during 7 months, were asked to complete an anonymous questionnaire containing the 9-item Morisky Medication Adherence Scale (MMAS) and questions about other factors potentially affecting adherence. The summary score of MMAS ranges from 1 to 13, where 13 indicates perfect adherence; patients scoring 11 or above (corresponding to 95% adherence level) were classified as 'adherent'. Results and discussion: In total 946 patients participated (response rate 97.5%). The proportion of patients who reported not missing a dose during the day prior to the completion of the questionnaire was 97% and the proportion classified as 'adherent' was 63%. 'Adherent' patients were more likely to have a good relationship with their health care professionals (P <0.05) and not have problems with drugs or alcohol (P <0.01). Being older (P <0.01) and having a shorter time on current treatment (P <0.01) and on treatment in total (P <0.05) were factors also associated with good adherence. Conclusion: Factors modifiable for interventions by health care professionals are patient-provider relationship, drug or alcohol problems and patients with long treatment periods. © 2006 The Authors.
    Original languageEnglish
    Pages (from-to)605-616
    Number of pages11
    JournalJournal of clinical pharmacy and therapeutics
    Volume31
    Issue number6
    DOIs
    Publication statusPublished - Dec 2006

    Keywords

    • Acquired immunodeficiency syndrome
    • Highly active antiretroviral therapy
    • Human immunodeficiency virus
    • Patient compliance
    • Sweden

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