Adipose-derived stem cells and nerve regeneration: Promises and pitfalls

Alessandro Faroni, Giorgio Terenghi, Adam J. Reid

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    In order to improve the outcome of nerve regeneration following peripheral trauma injuries, the development of bioengineered nerve grafts has attracted great attention in the field of tissue engineering. Adult stem cells constitute the ideal alternative to Schwann cells (SCs) as transplantable cells in bioartificial nerve grafts. Among the various sources of stem cells with potential applications for regenerative medicine, the adipose tissue has been proven to be one of the most promising. Adipose-derived stem cells (ASCs) are easily obtained, rapidly expanded, show low immunogenicity, and can be differentiated into SCs in vitro. This chapter will focus on recent advances in the use of differentiated and undifferentiated ASCs for peripheral nerve regeneration, with a critical attention for the clinical exploitability of ASC in nerve repair strategies. © 2013 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)121-136
    Number of pages15
    JournalInternational Review of Neurobiology
    Volume108
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Adipose-derived stem cells
    • Nerve regeneration
    • Peripheral nerves
    • Regenerative medicine
    • Tissue engineering

    Fingerprint

    Dive into the research topics of 'Adipose-derived stem cells and nerve regeneration: Promises and pitfalls'. Together they form a unique fingerprint.

    Cite this