Adipose-derived stem cells; selecting for translational success

KJ Johal, VC Lees, AJ Reid

    Research output: Contribution to journalReview articlepeer-review


    We have witnessed a rapid expansion of in vitro characterization and differentiation of adipose-derived stem cells, with increasing translation to both in vivo models and a breadth of clinical specialties. However, an appreciation of the truly heterogeneous nature of this unique stem cell group has identified a need to more accurately delineate subpopulations by any of a host of methods, to include functional properties or surface marker expression. Cells selected for improved proliferative, differentiative, angiogenic or ischemia-resistant properties are but a few attributes that could prove beneficial for targeted treatments or therapies. Optimizing cell culture conditions to permit re-introduction to patients is critical for clinical translation.
    Original languageEnglish
    Pages (from-to)79-96
    Number of pages17
    JournalRegenerative Medicine
    Issue number1
    Publication statusPublished - Jan 2015


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