Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Nicola Flaum; Richard Hubner; Juan Valle; Eitan Amir; Mairead Mcnamara

doi:10.1002/jso.25440

Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Nicola Flaum, Richard Hubner, Juan Valle, Eitan Amir, Mairead Mcnamara

Division of Cancer Sciences (L5)

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Abstract

Adjuvant chemotherapy (AC) following pancreatic carcinoma (PC) resection improves overall survival (OS). A systematic review identified 10 phase-2/3 studies investigating AC in 3644 patients looking at the influence of nodal and resection status. AC significantly improved DFS, OS and 5-year odds of death risk. There was greater survival benefit in patients PS 0 and with body/tail tumors. There was a non-significant effect in N-/N+ patients on OS and no difference between R0/R1 patients.

Original language	English
Journal	Journal of Surgical Oncology
Early online date	5 Mar 2019
DOIs	https://doi.org/10.1002/jso.25440
Publication status	Published - 2019

Keywords

pancreatic cancer
meta-analysis
systematic review
adjuvant chemotherapy
resection margin
lymph nodes

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.25440

2019-02-21-Final-HPB meta-analysis JSOAccepted author manuscript, 1.13 MB

Cite this

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title = "Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis",

abstract = "Adjuvant chemotherapy (AC) following pancreatic carcinoma (PC) resection improves overall survival (OS). A systematic review identified 10 phase-2/3 studies investigating AC in 3644 patients looking at the influence of nodal and resection status. AC significantly improved DFS, OS and 5-year odds of death risk. There was greater survival benefit in patients PS 0 and with body/tail tumors. There was a non-significant effect in N-/N+ patients on OS and no difference between R0/R1 patients.",

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T1 - Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

AU - Flaum, Nicola

AU - Hubner, Richard

AU - Valle, Juan

AU - Amir, Eitan

AU - Mcnamara, Mairead

PY - 2019

Y1 - 2019

N2 - Adjuvant chemotherapy (AC) following pancreatic carcinoma (PC) resection improves overall survival (OS). A systematic review identified 10 phase-2/3 studies investigating AC in 3644 patients looking at the influence of nodal and resection status. AC significantly improved DFS, OS and 5-year odds of death risk. There was greater survival benefit in patients PS 0 and with body/tail tumors. There was a non-significant effect in N-/N+ patients on OS and no difference between R0/R1 patients.

AB - Adjuvant chemotherapy (AC) following pancreatic carcinoma (PC) resection improves overall survival (OS). A systematic review identified 10 phase-2/3 studies investigating AC in 3644 patients looking at the influence of nodal and resection status. AC significantly improved DFS, OS and 5-year odds of death risk. There was greater survival benefit in patients PS 0 and with body/tail tumors. There was a non-significant effect in N-/N+ patients on OS and no difference between R0/R1 patients.

KW - pancreatic cancer

KW - meta-analysis

KW - systematic review

KW - adjuvant chemotherapy

KW - resection margin

KW - lymph nodes

U2 - 10.1002/jso.25440

DO - 10.1002/jso.25440

M3 - Article

SN - 0022-4790

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

ER -

Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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