Adjuvant chemotherapy and outcomes in patients with nodal and resection margin-negative pancreatic ductal adenocarcinoma: A systematic review and meta-analysis

Nicola Flaum, Richard Hubner, Juan Valle, Eitan Amir, Mairead Mcnamara

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Abstract

Adjuvant chemotherapy (AC) following pancreatic carcinoma (PC) resection improves overall survival (OS). A systematic review identified 10 phase-2/3 studies investigating AC in 3644 patients looking at the influence of nodal and resection status. AC significantly improved DFS, OS and 5-year odds of death risk. There was greater survival benefit in patients PS 0 and with body/tail tumors. There was a non-significant effect in N-/N+ patients on OS and no difference between R0/R1 patients.
Original languageEnglish
JournalJournal of Surgical Oncology
Early online date5 Mar 2019
DOIs
Publication statusPublished - 2019

Keywords

  • pancreatic cancer
  • meta-analysis
  • systematic review
  • adjuvant chemotherapy
  • resection margin
  • lymph nodes

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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