Administering amphotericin b-a practical approach

S. H. Khoo, Jeanette Bond, David W. Denning*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite the introduction in recent years of novel antifungal agents, the potency and broad spectrum of activity of amphotericin B have ensured that it remains the treatment of choice for most deep-seated mycoses. However, this agent is not without significant toxicity, particularly in patients who are already seriously ill and/or who are receiving other potentially nephrotoxic drugs. We review the various routes by which amphotericin B can be administered, focusing mainly on the intravenous route. The use of more rapid infusion rates, lipid-complexed preparations, sodium supplementation in salt-depleted patients and stategies to reduce the incidence of infusion-related reactions and nephrotoxicity are also considered. Finally, detailed recommendations for the administration of amphotericin B are provided.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalJournal of Antimicrobial Chemotherapy
Volume33
Issue number2
DOIs
Publication statusPublished - 1 Feb 1994

Keywords

  • Amphotericin B
  • Infusions, Intravenous
  • Drug Interactions

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