Abstract
Despite the introduction in recent years of novel antifungal agents, the potency and broad spectrum of activity of amphotericin B have ensured that it remains the treatment of choice for most deep-seated mycoses. However, this agent is not without significant toxicity, particularly in patients who are already seriously ill and/or who are receiving other potentially nephrotoxic drugs. We review the various routes by which amphotericin B can be administered, focusing mainly on the intravenous route. The use of more rapid infusion rates, lipid-complexed preparations, sodium supplementation in salt-depleted patients and stategies to reduce the incidence of infusion-related reactions and nephrotoxicity are also considered. Finally, detailed recommendations for the administration of amphotericin B are provided.
Original language | English |
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Pages (from-to) | 203-213 |
Number of pages | 11 |
Journal | Journal of Antimicrobial Chemotherapy |
Volume | 33 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 1994 |
Keywords
- Amphotericin B
- Infusions, Intravenous
- Drug Interactions