Adverse reactions to voriconazole

Aileen E. Boyd; Simon Modi; Susan J. Howard; Caroline B. Moore; Brian G. Keevil; David W. Denning

doi:10.1086/424662

Adverse reactions to voriconazole

Aileen E. Boyd, Simon Modi, Susan J. Howard, Caroline B. Moore, Brian G. Keevil, David W. Denning

Research output: Contribution to journal › Article › peer-review

Abstract

Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable - more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.

Original language	English
Pages (from-to)	1241-1244
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	39
Issue number	8
DOIs	https://doi.org/10.1086/424662
Publication status	Published - 15 Oct 2004

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title = "Adverse reactions to voriconazole",

abstract = "Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable - more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.",

author = "Boyd, {Aileen E.} and Simon Modi and Howard, {Susan J.} and Moore, {Caroline B.} and Keevil, {Brian G.} and Denning, {David W.}",

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AU - Boyd, Aileen E.

AU - Modi, Simon

AU - Howard, Susan J.

AU - Moore, Caroline B.

AU - Keevil, Brian G.

AU - Denning, David W.

PY - 2004/10/15

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AB - Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable - more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.

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DO - 10.1086/424662

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EP - 1244

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

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Adverse reactions to voriconazole

Abstract

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