Adverse reactions to voriconazole

Aileen E. Boyd, Simon Modi, Susan J. Howard, Caroline B. Moore, Brian G. Keevil, David W. Denning

    Research output: Contribution to journalArticlepeer-review


    Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable - more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.
    Original languageEnglish
    Pages (from-to)1241-1244
    Number of pages3
    JournalClinical Infectious Diseases
    Issue number8
    Publication statusPublished - 15 Oct 2004


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