AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer

V. Saha; D. M. Lillington; A. N. Shelling; T. Chaplin; M. L. Yaspo; T. S. Ganesan; B. D. Young

doi:10.1002/gcc.2870140311

AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer

V. Saha, D. M. Lillington, A. N. Shelling, T. Chaplin, M. L. Yaspo, T. S. Ganesan, B. D. Young

Research output: Contribution to journal › Article › peer-review

Abstract

Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C-109F0645 was isolated. By fluorescence in situ hybridization, C-109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.

Original language	English
Pages (from-to)	220-222
Number of pages	2
Journal	Genes Chromosomes and Cancer
Volume	14
Issue number	3
DOIs	https://doi.org/10.1002/gcc.2870140311
Publication status	Published - 1995

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10.1002/gcc.2870140311

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@article{878b1423609f4de293f2030b542a60a1,

title = "AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer",

abstract = "Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C-109F0645 was isolated. By fluorescence in situ hybridization, C-109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.",

author = "V. Saha and Lillington, {D. M.} and Shelling, {A. N.} and T. Chaplin and Yaspo, {M. L.} and Ganesan, {T. S.} and Young, {B. D.}",

year = "1995",

doi = "10.1002/gcc.2870140311",

language = "English",

volume = "14",

pages = "220--222",

journal = "Genes Chromosomes and Cancer",

issn = "1045-2257",

publisher = "John Wiley & Sons Ltd",

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}

TY - JOUR

T1 - AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer

AU - Saha, V.

AU - Lillington, D. M.

AU - Shelling, A. N.

AU - Chaplin, T.

AU - Yaspo, M. L.

AU - Ganesan, T. S.

AU - Young, B. D.

PY - 1995

Y1 - 1995

N2 - Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C-109F0645 was isolated. By fluorescence in situ hybridization, C-109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.

AB - Chromosome 6 has been shown to contain at band q27 a minimal region of deletion associated with epithelial ovarian cancers and AF6, a gene disrupted in acute myeloid leukemia with t(6;11)(q27;q23). Using rapid amplification of cDNA ends by polymerase chain reaction, the breakpoint in AF6 was confirmed and a cDNA clone identified. This clone was used as a probe to screen a chromosome 6 cosmid library, and a single cosmid C-109F0645 was isolated. By fluorescence in situ hybridization, C-109F0465 was found to map distal to the critically deleted region associated with ovarian malignancies. AF6 is therefore distinct from and lies telomeric to this region.

U2 - 10.1002/gcc.2870140311

DO - 10.1002/gcc.2870140311

M3 - Article

C2 - 8589040

SN - 1045-2257

VL - 14

SP - 220

EP - 222

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

IS - 3

ER -

AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer

Abstract

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