@article{1e4dcaf56b7848aca32892a72b323e30,
title = "Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged.",
abstract = "The incidence of heart failure (HF) increases with age. This study sought to determine whether aging exacerbates structural and functional remodeling of the myocardium in HF. HF was induced in young (~18 months) and aged sheep (>8 years) by right ventricular tachypacing. In non-paced animals, aging was associated with increased left ventricular (LV) end diastolic internal dimensions (EDID, P",
keywords = "Aging, Extracellular matrix, Fibrosis, Heart failure, TIMPs",
author = "Horn, {Margaux A} and Graham, {Helen K} and Richards, {Mark A} and Clarke, {Jessica D} and Greensmith, {David J} and Briston, {Sarah J} and Hall, {Mark C S} and Dibb, {Katharine M} and Trafford, {Andrew W}",
note = "CH/2000004, British Heart Foundation, United KingdomFS/09/002/26487, British Heart Foundation, United KingdomFS/09/036, British Heart Foundation, United KingdomFS/09/036/27823, British Heart Foundation, United KingdomPG/07/099, British Heart Foundation, United KingdomPG/07/099/23758, British Heart Foundation, United KingdomPG/07/124, British Heart Foundation, United KingdomPG/08/078, British Heart Foundation, United KingdomPG/09/062, British Heart Foundation, United KingdomPG/09/062/27872, British Heart Foundation, United Kingdom",
year = "2012",
month = jul,
doi = "10.1016/j.yjmcc.2012.03.011",
language = "English",
volume = "53",
pages = "82--90",
journal = "Journal of molecular and cellular cardiology",
issn = "1095-8584",
publisher = "Academic Press",
number = "1",
}