Age-related macular degeneration and the role of the complement system.

Selina Mcharg; Simon J Clark; Anthony J Day; Paul N Bishop

doi:10.1016/j.molimm.2015.02.032

Age-related macular degeneration and the role of the complement system.

Selina Mcharg, Simon J Clark, Anthony J Day, Paul N Bishop

Research output: Contribution to journal › Article › peer-review

Abstract

Age-related macular degeneration (AMD) is a leading cause of visual impairment. It is characterised by damage to a tissue complex composed of the retinal pigment epithelium, Bruch's membrane and choriocapillaris. In early AMD extracellular debris including drusen accumulates in Bruch's membrane and then in late AMD geographic atrophy and/or neovascularisation develop. Variants in genes encoding components of the alternative pathway of the complement cascade have a major influence on AMD risk, especially at the RCA locus on chromosome 1, which contains CFH and the CFHR genes. Immunohistochemical studies have demonstrated complement components in unaffected and AMD macular tissue. Whilst other factors, including oxidative stress, play important roles in AMD pathogenesis, evidence for the central role played by complement dysregulation is discussed in this review.

Original language	English
Pages (from-to)	43-50
Number of pages	7
Journal	Molecular immunology
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/j.molimm.2015.02.032
Publication status	Published - Sept 2015

Keywords

Age-related macular degeneration
Alternative pathway
Complement system

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10.1016/j.molimm.2015.02.032

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title = "Age-related macular degeneration and the role of the complement system.",

abstract = "Age-related macular degeneration (AMD) is a leading cause of visual impairment. It is characterised by damage to a tissue complex composed of the retinal pigment epithelium, Bruch's membrane and choriocapillaris. In early AMD extracellular debris including drusen accumulates in Bruch's membrane and then in late AMD geographic atrophy and/or neovascularisation develop. Variants in genes encoding components of the alternative pathway of the complement cascade have a major influence on AMD risk, especially at the RCA locus on chromosome 1, which contains CFH and the CFHR genes. Immunohistochemical studies have demonstrated complement components in unaffected and AMD macular tissue. Whilst other factors, including oxidative stress, play important roles in AMD pathogenesis, evidence for the central role played by complement dysregulation is discussed in this review.",

keywords = "Age-related macular degeneration, Alternative pathway, Complement system",

author = "Selina Mcharg and Clark, {Simon J} and Day, {Anthony J} and Bishop, {Paul N}",

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T1 - Age-related macular degeneration and the role of the complement system.

AU - Mcharg, Selina

AU - Clark, Simon J

AU - Day, Anthony J

AU - Bishop, Paul N

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N2 - Age-related macular degeneration (AMD) is a leading cause of visual impairment. It is characterised by damage to a tissue complex composed of the retinal pigment epithelium, Bruch's membrane and choriocapillaris. In early AMD extracellular debris including drusen accumulates in Bruch's membrane and then in late AMD geographic atrophy and/or neovascularisation develop. Variants in genes encoding components of the alternative pathway of the complement cascade have a major influence on AMD risk, especially at the RCA locus on chromosome 1, which contains CFH and the CFHR genes. Immunohistochemical studies have demonstrated complement components in unaffected and AMD macular tissue. Whilst other factors, including oxidative stress, play important roles in AMD pathogenesis, evidence for the central role played by complement dysregulation is discussed in this review.

AB - Age-related macular degeneration (AMD) is a leading cause of visual impairment. It is characterised by damage to a tissue complex composed of the retinal pigment epithelium, Bruch's membrane and choriocapillaris. In early AMD extracellular debris including drusen accumulates in Bruch's membrane and then in late AMD geographic atrophy and/or neovascularisation develop. Variants in genes encoding components of the alternative pathway of the complement cascade have a major influence on AMD risk, especially at the RCA locus on chromosome 1, which contains CFH and the CFHR genes. Immunohistochemical studies have demonstrated complement components in unaffected and AMD macular tissue. Whilst other factors, including oxidative stress, play important roles in AMD pathogenesis, evidence for the central role played by complement dysregulation is discussed in this review.

KW - Age-related macular degeneration

KW - Alternative pathway

KW - Complement system

U2 - 10.1016/j.molimm.2015.02.032

DO - 10.1016/j.molimm.2015.02.032

M3 - Article

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SN - 1872-9142

VL - 67

SP - 43

EP - 50

JO - Molecular immunology

JF - Molecular immunology

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ER -

Age-related macular degeneration and the role of the complement system.

Abstract

Keywords

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