Age-related macular degeneration: The importance of family history as a risk factor

Paul Bishop; Humma Shahid; Jane C. Khan; Valentina Cipriani; Tiina Sepp; Baljinder K. Matharu; Catey Bunce; Simon P. Harding; David G. Clayton; Anthony T. Moore; John R W Yates

doi:10.1136/bjophthalmol-2011-300193

Age-related macular degeneration: The importance of family history as a risk factor

Paul Bishop, Humma Shahid, Jane C. Khan, Valentina Cipriani, Tiina Sepp, Baljinder K. Matharu, Catey Bunce, Simon P. Harding, David G. Clayton, Anthony T. Moore, John R W Yates

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Family history is considered a risk factor for age-related macular degeneration (AMD). With the advent of effective therapy for the disease, the importance of family history merits further investigation. This study quantifies the risk associated with family history, first, by a case-control study of reported family history and, second, by examining the siblings of AMD cases. Methods: The authors recruited cases with advanced AMD, spouses and siblings. All subjects were carefully phenotyped. Clinical findings in the siblings were compared with spouses. Information about family history was collected. The ORs for reported family history of AMD were calculated. Analyses were adjusted for age, smoking and genotype. Results: 495 AMD cases, 259 spouses and 171 siblings were recruited. The OR for AMD was 27.8 (CI 3.8 to 203.0; p=0.001) with a reported family history of an affected parent and 12.0 (CI 3.7 to 38.6; p

Original language	English
Pages (from-to)	427-431
Number of pages	4
Journal	British Journal Of Ophthalmology
Volume	96
Issue number	3
DOIs	https://doi.org/10.1136/bjophthalmol-2011-300193
Publication status	Published - Mar 2012

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http://bjo.bmj.com/content/96/3/427.full.pdf+html

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title = "Age-related macular degeneration: The importance of family history as a risk factor",

abstract = "Background: Family history is considered a risk factor for age-related macular degeneration (AMD). With the advent of effective therapy for the disease, the importance of family history merits further investigation. This study quantifies the risk associated with family history, first, by a case-control study of reported family history and, second, by examining the siblings of AMD cases. Methods: The authors recruited cases with advanced AMD, spouses and siblings. All subjects were carefully phenotyped. Clinical findings in the siblings were compared with spouses. Information about family history was collected. The ORs for reported family history of AMD were calculated. Analyses were adjusted for age, smoking and genotype. Results: 495 AMD cases, 259 spouses and 171 siblings were recruited. The OR for AMD was 27.8 (CI 3.8 to 203.0; p=0.001) with a reported family history of an affected parent and 12.0 (CI 3.7 to 38.6; p",

author = "Paul Bishop and Humma Shahid and Khan, {Jane C.} and Valentina Cipriani and Tiina Sepp and Matharu, {Baljinder K.} and Catey Bunce and Harding, {Simon P.} and Clayton, {David G.} and Moore, {Anthony T.} and Yates, {John R W}",

year = "2012",

month = mar,

doi = "10.1136/bjophthalmol-2011-300193",

language = "English",

volume = "96",

pages = "427--431",

journal = "British Journal Of Ophthalmology",

issn = "0007-1161",

publisher = "BMJ ",

number = "3",

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T1 - Age-related macular degeneration: The importance of family history as a risk factor

AU - Bishop, Paul

AU - Shahid, Humma

AU - Khan, Jane C.

AU - Cipriani, Valentina

AU - Sepp, Tiina

AU - Matharu, Baljinder K.

AU - Bunce, Catey

AU - Harding, Simon P.

AU - Clayton, David G.

AU - Moore, Anthony T.

AU - Yates, John R W

PY - 2012/3

Y1 - 2012/3

N2 - Background: Family history is considered a risk factor for age-related macular degeneration (AMD). With the advent of effective therapy for the disease, the importance of family history merits further investigation. This study quantifies the risk associated with family history, first, by a case-control study of reported family history and, second, by examining the siblings of AMD cases. Methods: The authors recruited cases with advanced AMD, spouses and siblings. All subjects were carefully phenotyped. Clinical findings in the siblings were compared with spouses. Information about family history was collected. The ORs for reported family history of AMD were calculated. Analyses were adjusted for age, smoking and genotype. Results: 495 AMD cases, 259 spouses and 171 siblings were recruited. The OR for AMD was 27.8 (CI 3.8 to 203.0; p=0.001) with a reported family history of an affected parent and 12.0 (CI 3.7 to 38.6; p

AB - Background: Family history is considered a risk factor for age-related macular degeneration (AMD). With the advent of effective therapy for the disease, the importance of family history merits further investigation. This study quantifies the risk associated with family history, first, by a case-control study of reported family history and, second, by examining the siblings of AMD cases. Methods: The authors recruited cases with advanced AMD, spouses and siblings. All subjects were carefully phenotyped. Clinical findings in the siblings were compared with spouses. Information about family history was collected. The ORs for reported family history of AMD were calculated. Analyses were adjusted for age, smoking and genotype. Results: 495 AMD cases, 259 spouses and 171 siblings were recruited. The OR for AMD was 27.8 (CI 3.8 to 203.0; p=0.001) with a reported family history of an affected parent and 12.0 (CI 3.7 to 38.6; p

U2 - 10.1136/bjophthalmol-2011-300193

DO - 10.1136/bjophthalmol-2011-300193

M3 - Article

SN - 0007-1161

VL - 96

SP - 427

EP - 431

JO - British Journal Of Ophthalmology

JF - British Journal Of Ophthalmology

IS - 3

ER -

Age-related macular degeneration: The importance of family history as a risk factor

Abstract

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