Age-related macular degeneration: The importance of family history as a risk factor

Paul Bishop, Humma Shahid, Jane C. Khan, Valentina Cipriani, Tiina Sepp, Baljinder K. Matharu, Catey Bunce, Simon P. Harding, David G. Clayton, Anthony T. Moore, John R W Yates

    Research output: Contribution to journalArticlepeer-review


    Background: Family history is considered a risk factor for age-related macular degeneration (AMD). With the advent of effective therapy for the disease, the importance of family history merits further investigation. This study quantifies the risk associated with family history, first, by a case-control study of reported family history and, second, by examining the siblings of AMD cases. Methods: The authors recruited cases with advanced AMD, spouses and siblings. All subjects were carefully phenotyped. Clinical findings in the siblings were compared with spouses. Information about family history was collected. The ORs for reported family history of AMD were calculated. Analyses were adjusted for age, smoking and genotype. Results: 495 AMD cases, 259 spouses and 171 siblings were recruited. The OR for AMD was 27.8 (CI 3.8 to 203.0; p=0.001) with a reported family history of an affected parent and 12.0 (CI 3.7 to 38.6; p
    Original languageEnglish
    Pages (from-to)427-431
    Number of pages4
    JournalBritish Journal Of Ophthalmology
    Issue number3
    Publication statusPublished - Mar 2012


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