Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma

G. P. Currie, S. J. Fowler, A. M. Wilson, E. J. Sims, L. C. Orr, B. J. Lipworth

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: With the transition to hydrofluoroalkane-134a propellants in metered dose inhalers, it is important to consider the efficacy and safety profiles of formulations containing inhaled corticosteroids. We examined the airway and systemic effects of hydrofluoroalkane-134a fluticasone propionate (FLU-HFA) and beclomethasone dipropionate (BEC-HFA) at recommended labelled doses. Methods: Twenty mild to moderate asthmatics were randomised in crossover fashion to receive 6 weeks of 500 μg/day followed by 1000 μg/day FLU-HFA and BEC-HFA. Measurements were made at baseline after placebo run in and washout, and after each randomised treatment. The primary airway outcome for benefit was the dose of methacholine provoking a fall in forced expiratory volume in 1 second (FEV1) of 20% or more (methacholine PD20) and for systemic adverse effects was overnight urinary cortisol/creatinine (OUCC). Results: For mean responses, both doses of BEC-HFA and FLU-HFA produced significant improvements in PD20 compared with baseline. The improvement was not significantly greater with 1000 μg/day FLU-HFA versus BEC-HFA, a 1.69 fold difference (95% Cl 0.94 to 3.04). Both doses of BEC-HFA but not FLU-HFA caused significant suppression of OUCC compared with baseline, with significantly (p
    Original languageEnglish
    Pages (from-to)865-868
    Number of pages3
    JournalThorax
    Volume57
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2002

    Keywords

    • Adult
    • administration & dosage: Androstadienes
    • administration & dosage: Anti-Asthmatic Agents
    • drug therapy: Asthma
    • administration & dosage: Beclomethasone
    • administration & dosage: Bronchoconstrictor Agents
    • administration & dosage: Bronchodilator Agents
    • metabolism: Creatinine
    • Cross-Over Studies
    • Dose-Response Relationship, Drug
    • Female
    • Forced Expiratory Flow Rates
    • drug effects: Forced Expiratory Volume
    • Humans
    • administration & dosage: Hydrocarbons, Fluorinated
    • urine: Hydrocortisone
    • Male
    • diagnostic use: Methacholine Chloride
    • Research Support, Non-U.S. Gov't

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