TY - JOUR
T1 - Albumin loaded PEO coatings on Ti - Potential as drug eluting systems
AU - Martínez Campos, E.
AU - Santos-Coquillat, A.
AU - Mingo, B.
AU - Arrabal, R.
AU - Mohedano, M.
AU - Pardo, A.
AU - Ramos, V.
AU - López Lacomba, J. L.
AU - Matykina, E.
PY - 2015/12/15
Y1 - 2015/12/15
N2 - Protein release potential of plasma electrolytic oxidation coatings formed on commercially pure titaniumdirectly loaded with bovine serum albumin was investigated. Four types of coatings with thicknesses of 5 and 15 μm, graded porosity, roughness and composition were studied. The TiO2 coatings were enriched with calcium (3.7-11.1 at.%) and phosphorus (1.5-6.5 at.%). Albumin delivery capacity evaluated during 48 h appears to depend on coating composition, rather than on volume porosity. The coating with Ca/P ratio of 4.0 and no crystalline CaP compounds liberated BSA faster than non-coated Ti CP control in the first 12 h and eluted the entire load in 48 h. The coatingswith Ca/P ratio of 1.5-2.0 liberated about 15% of the load over the sameperiod, independently of the surface and volume porosity. Albumin adhesion to the surface and, consequently, retention has been related to its interaction with Ca and P in the coatings. PEO coatings have potential for incorporation and release of growth factors, antibiotics, anti-inflammatory agents, etc. This strategy can be applied in the biomedical field in order to reduce dental implant associated pathologies.
AB - Protein release potential of plasma electrolytic oxidation coatings formed on commercially pure titaniumdirectly loaded with bovine serum albumin was investigated. Four types of coatings with thicknesses of 5 and 15 μm, graded porosity, roughness and composition were studied. The TiO2 coatings were enriched with calcium (3.7-11.1 at.%) and phosphorus (1.5-6.5 at.%). Albumin delivery capacity evaluated during 48 h appears to depend on coating composition, rather than on volume porosity. The coating with Ca/P ratio of 4.0 and no crystalline CaP compounds liberated BSA faster than non-coated Ti CP control in the first 12 h and eluted the entire load in 48 h. The coatingswith Ca/P ratio of 1.5-2.0 liberated about 15% of the load over the sameperiod, independently of the surface and volume porosity. Albumin adhesion to the surface and, consequently, retention has been related to its interaction with Ca and P in the coatings. PEO coatings have potential for incorporation and release of growth factors, antibiotics, anti-inflammatory agents, etc. This strategy can be applied in the biomedical field in order to reduce dental implant associated pathologies.
KW - Albumin
KW - Coating(s)
KW - Drug delivery
KW - Plasma electrolytic oxidation
KW - Titanium (alloys)
UR - http://www.scopus.com/inward/record.url?scp=84949423362&partnerID=8YFLogxK
U2 - 10.1016/j.surfcoat.2015.10.045
DO - 10.1016/j.surfcoat.2015.10.045
M3 - Article
AN - SCOPUS:84949423362
VL - 283
SP - 44
EP - 51
JO - Surface and Coatings Technology
JF - Surface and Coatings Technology
SN - 0257-8972
ER -