Albumin loaded PEO coatings on Ti - Potential as drug eluting systems

E. Martínez Campos, A. Santos-Coquillat, B. Mingo, R. Arrabal, M. Mohedano, A. Pardo, V. Ramos, J. L. López Lacomba, E. Matykina

    Research output: Contribution to journalArticlepeer-review


    Protein release potential of plasma electrolytic oxidation coatings formed on commercially pure titaniumdirectly loaded with bovine serum albumin was investigated. Four types of coatings with thicknesses of 5 and 15 μm, graded porosity, roughness and composition were studied. The TiO2 coatings were enriched with calcium (3.7-11.1 at.%) and phosphorus (1.5-6.5 at.%). Albumin delivery capacity evaluated during 48 h appears to depend on coating composition, rather than on volume porosity. The coating with Ca/P ratio of 4.0 and no crystalline CaP compounds liberated BSA faster than non-coated Ti CP control in the first 12 h and eluted the entire load in 48 h. The coatingswith Ca/P ratio of 1.5-2.0 liberated about 15% of the load over the sameperiod, independently of the surface and volume porosity. Albumin adhesion to the surface and, consequently, retention has been related to its interaction with Ca and P in the coatings. PEO coatings have potential for incorporation and release of growth factors, antibiotics, anti-inflammatory agents, etc. This strategy can be applied in the biomedical field in order to reduce dental implant associated pathologies.

    Original languageEnglish
    Pages (from-to)44-51
    Number of pages8
    JournalSurface and Coatings Technology
    Publication statusPublished - 15 Dec 2015


    • Albumin
    • Coating(s)
    • Drug delivery
    • Plasma electrolytic oxidation
    • Titanium (alloys)


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