Aligned multi-walled carbon nanotubes with nanohydroxyapatite in a 3D printed polycaprolactone scaffold stimulates osteogenic differentiation

Boyang Huang, Cian Vyas, Jae Jong Byun, Mohamed El-Newehy, Zhucheng Huang, Paulo Jorge Da Silva Bartolo

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Abstract

The development of highly biomimetic scaffolds in terms of composition and structures, to repair or replace damaged bone tissues, is particularly relevant for tissue engineering. This paper investigates a 3D printed porous scaffold containing aligned multi-walled carbon nanotubes (MWCNTs) and nano-hydroxyapatite (nHA), mi- micking the natural bone tissue from the nanoscale to macroscale level. MWCNTs with similar dimensions as collagen fibres are coupled with nHA and mixed within a polycaprolactone (PCL) matrix to produce scaffolds using a screw-assisted extrusion-based additive manufacturing system. Scaffolds with different material com- positions were extensively characterised from morphological, mechanical and biological points of views. Transmission electron microscopy and polarised Raman spectroscopy confirm the presence of aligned MWCNTs within the printed filaments. The PCL/HA/MWCNTs scaffold are similar to the nanostructure of native bone and shows overall increased mechanical properties, cell proliferation, osteogenic differentiation and scaffold mi- neralisation, indicating a promising approach for bone tissue regeneration.
Original languageEnglish
Article number110374
JournalMaterials Science and Engineering C
Volume108
Early online date9 Nov 2019
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • Additive Manufacturing
  • Bone Scaffolds
  • Hierarchical structures
  • Hydroxyapatite
  • Multi-walled carbon nanotubes

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