TY - JOUR
T1 - ALK-negative anaplastic large cell lymphoma: features and outcomes of 235 patients from the International T-Cell Project
AU - Shustov, Andrei
AU - Cabrera, Maria Elena
AU - Civallero, Monica
AU - Hyeh Ko, Young
AU - Manni, Martina
AU - Skrypets, Tetiana
AU - Horwitz, Steven M
AU - de Souza, Carmino Antonio
AU - Radford, J
AU - Bobillo, Sabela
AU - Prates, Maria Virginia
AU - Ferreri, Andres J M
AU - Spina, Mechele
AU - Vose, Julie M
AU - Chiappella, Annalisa
AU - Laszlo, Daniele
AU - Stelitano, Caterina
AU - Frederico, Massimo
N1 - Publisher Copyright:
© 2021 by The American Society of Hematology
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/9
Y1 - 2021/2/9
N2 - Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK
- ALCL) is an aggressive neoplasm of T-cell/null-cell lineage. The T-Cell Project is a global prospective cohort study that consecutively enrolled patients newly diagnosed with peripheral T-cell lymphoma, registered through a centralized computer database between September 2006 and February 2018. Of 1553 validated cases from 74 sites in 13 countries worldwide, 235 were reported as ALK
- ALCL. The median age at diagnosis was 54 years (range, 18-89 years), with a male predominance (62%). Stage III to IV disease was identified in 71% of patients, bulky disease and bone marrow involvement were uncommon, and 66% of patients presented with a low (0-1) International Prognostic Index score. Of all treated patients, 85% received multiagent initial chemotherapy, and 8% were consolidated with autologous hematopoietic cell transplantation. The initial overall and complete response rates were 77% and 63%, respectively. After a median follow-up of 52 months (95% confidence interval [CI], 41-63), the median progression-free survival (PFS) and overall survival (OS) were 41 months (95% CI, 17-62) and 55 months (95% CI, 36-75), respectively. The 3- and 5-year PFS rates were 52% and 43%, and the 3- and 5-year OS rates were 60% and 49%. Treatments containing both anthracycline and etoposide were associated with superior OS (P 5.05) but not PFS (P 5.18). In this large prospective cohort study, outcomes comparable to those previously reported in the retrospective International Peripheral T-Cell Lymphoma Project were observed. The study underscores the need for introducing novel platforms for ALK
- ALCL and establishes a benchmark for future clinical trials. This trial was registered at www.clinicaltrials.gov as #NCT01142674.
AB - Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK
- ALCL) is an aggressive neoplasm of T-cell/null-cell lineage. The T-Cell Project is a global prospective cohort study that consecutively enrolled patients newly diagnosed with peripheral T-cell lymphoma, registered through a centralized computer database between September 2006 and February 2018. Of 1553 validated cases from 74 sites in 13 countries worldwide, 235 were reported as ALK
- ALCL. The median age at diagnosis was 54 years (range, 18-89 years), with a male predominance (62%). Stage III to IV disease was identified in 71% of patients, bulky disease and bone marrow involvement were uncommon, and 66% of patients presented with a low (0-1) International Prognostic Index score. Of all treated patients, 85% received multiagent initial chemotherapy, and 8% were consolidated with autologous hematopoietic cell transplantation. The initial overall and complete response rates were 77% and 63%, respectively. After a median follow-up of 52 months (95% confidence interval [CI], 41-63), the median progression-free survival (PFS) and overall survival (OS) were 41 months (95% CI, 17-62) and 55 months (95% CI, 36-75), respectively. The 3- and 5-year PFS rates were 52% and 43%, and the 3- and 5-year OS rates were 60% and 49%. Treatments containing both anthracycline and etoposide were associated with superior OS (P 5.05) but not PFS (P 5.18). In this large prospective cohort study, outcomes comparable to those previously reported in the retrospective International Peripheral T-Cell Lymphoma Project were observed. The study underscores the need for introducing novel platforms for ALK
- ALCL and establishes a benchmark for future clinical trials. This trial was registered at www.clinicaltrials.gov as #NCT01142674.
U2 - 10.1182/bloodadvances.2020001581
DO - 10.1182/bloodadvances.2020001581
M3 - Article
SN - 2473-9537
VL - 5
SP - 640
EP - 648
JO - Blood Advances
JF - Blood Advances
IS - 3
M1 - 3
ER -