Alkaloids as Alternative Probes to Characterize the Relative Hydrophobicity of Aqueous Biphasic Systems

Jorge F B Pereira, Agnes Magri, Maria V. Quental, Maria Gonzalez-Miquel, Mara G. Freire, João A P Coutinho

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In order to overcome the lack of characterization on the relative hydrophobicity of aqueous biphasic systems (ABS), the partition of three alkaloids as alternative probes was evaluated in a series of biocompatible ABS composed of cholinium-based salts or ionic liquids (ILs) and polyethylene glycol (PEG). The caffeine partitioning in ABS was first addressed to infer the effect of the phase-forming components composition. In all systems, caffeine preferentially concentrates in the lower water content PEG-rich phase. Additionally, a linear dependence between the logarithmic function of the partition coefficients and the water content ratio was found. To confirm this linear dependency, the partition coefficients of caffeine, theobromine, and theophylline were determined in other ABS formed by different cholinium-based salts/ILs. In most systems, it is shown that all alkaloids partition to the most hydrophobic phase. To support the experimental results, COSMO-RS (Conductor-like Screening Model for Real Solvents) was used to compute the screening charge distributions of the salts/IL components of ABS and alkaloids, excess enthalpy of mixing, and activity coefficients at infinite dilution. It is here demonstrated that the partition trend of alkaloids can be used to address the relative hydrophobicity of the coexisting phases in polymer-salt/IL ABS.

    Original languageEnglish
    Pages (from-to)1512-1520
    Number of pages9
    JournalACS Sustainable Chemistry & Engineering
    Volume4
    Issue number3
    Early online date26 Jan 2016
    DOIs
    Publication statusPublished - 7 Mar 2016

    Keywords

    • Alkaloid
    • Aqueous biphasic systems
    • Caffeine
    • Cholinium
    • Hydrophobicity
    • Ionic liquids
    • Polyethylene glycol
    • Theobromine
    • Theophylline

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