Alteration in platelet function in patients with early breast cancer

Garry McDowell, I. Temple, C. Li, C. C. Kirwan, N. J. Bundred, C. N. McCollum, I. E. Burton, S. Kumar, G. J. Byrne

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The aim of this study was to examine our hypothesis that platelets of patients with breast cancer were functionally altered compared to healthy controls. The results have shown that the platelets from women with early breast cancer released significantly more vascular endothelial growth factor (VEGF) when stimulated with thrombin, tissue factor, clotting, or over a period of time. Similarly, release of thrombospondin (TSP) with thrombin and tissue factor was higher, but failed to reach a significant level. Thus, the observed differences in platelet response support our hypothesis, but warrant further work to determine the reason underlying the observed difference and potential clinical relevance of our findings.
    Original languageEnglish
    Pages (from-to)3963-3966
    Number of pages3
    JournalAnticancer Research
    Volume25
    Issue number6 B
    Publication statusPublished - Nov 2005

    Keywords

    • Breast cancer
    • Platelets
    • Thrombospondin
    • Tissue factor
    • VEGF

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