Alterations in phencyclidine and sigma binding sites in schizophrenic brains: Effects of disease process and neuroleptic medication

D. M. Simpson, P Slater, M.C. Royston, J F Deakin

Research output: Contribution to journalArticlepeer-review

Abstract

The specific binding of [3H]TCP and [3H](+)3-PPP, radioligands which respectively label PCP-NMDA and sigma binding sites was measured in tissue homogenates prepared from dissected areas of control and schizophrenic postmortem brains. [3H]TCP binding was bilaterally increased in orbital frontal cortex (Brodmann area 11) of schizophrenic brains. This finding may be due to an increased glutamatergic innervation of orbital frontal cortex since it parallels our findings of increased [3H]kainate and [3H]D-aspartate binding in this area. In contrast, [3H](+)3-PPP binding was reduced in each of the four brain regions examined. The reductions were greatest in brains from the schizophrenic subjects receiving neuroleptics at the time of death. Neuroleptics remaining in the brains of these subjects may compete in vitro with [3H](+)3-PPP for binding to the sigma site.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalSchizophrenia Research
Volume6
Issue number1
Publication statusPublished - Dec 1991

Keywords

  • Antipsychotic Agents
  • Brain
  • Brain Mapping
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phencyclidine
  • Radioligand Assay
  • Receptors, Neurotransmitter
  • Receptors, Opioid
  • Receptors, Phencyclidine
  • Receptors, sigma
  • Schizophrenia
  • Schizophrenic Psychology
  • Street Drugs
  • Journal Article
  • Research Support, Non-U.S. Gov't

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