Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix

W. O F Alazawi, L. S. Morris, M. A. Stanley, D. R. Garrod, N. Coleman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs) were immunostained for desmosomal proteins and glycoproteins, and results were assessed using a semi-quantitative grading system. No difference between normal cervix and low-grade SIL (LSIL) was found. A significant reduction in expression of desmogleins was seen between high-grade SIL (HSIL) and LSIL (P
    Original languageEnglish
    Pages (from-to)51-56
    Number of pages5
    JournalVirchows Archiv
    Volume443
    Issue number1
    DOIs
    Publication statusPublished - 1 Jul 2003

    Keywords

    • Cervix
    • Desmocollin
    • Desmoglein
    • Desmoplakin
    • Desmosome
    • Neoplasia

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