Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix

W. O F Alazawi; L. S. Morris; M. A. Stanley; D. R. Garrod; N. Coleman

doi:10.1007/s00428-003-0771-9

Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix

W. O F Alazawi, L. S. Morris, M. A. Stanley, D. R. Garrod, N. Coleman

Research output: Contribution to journal › Article › peer-review

Abstract

We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs) were immunostained for desmosomal proteins and glycoproteins, and results were assessed using a semi-quantitative grading system. No difference between normal cervix and low-grade SIL (LSIL) was found. A significant reduction in expression of desmogleins was seen between high-grade SIL (HSIL) and LSIL (P

Original language	English
Pages (from-to)	51-56
Number of pages	5
Journal	Virchows Archiv
Volume	443
Issue number	1
DOIs	https://doi.org/10.1007/s00428-003-0771-9
Publication status	Published - 1 Jul 2003

Keywords

Cervix
Desmocollin
Desmoglein
Desmoplakin
Desmosome
Neoplasia

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10.1007/s00428-003-0771-9

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title = "Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix",

abstract = "We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs) were immunostained for desmosomal proteins and glycoproteins, and results were assessed using a semi-quantitative grading system. No difference between normal cervix and low-grade SIL (LSIL) was found. A significant reduction in expression of desmogleins was seen between high-grade SIL (HSIL) and LSIL (P",

keywords = "Cervix, Desmocollin, Desmoglein, Desmoplakin, Desmosome, Neoplasia",

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AU - Alazawi, W. O F

AU - Morris, L. S.

AU - Stanley, M. A.

AU - Garrod, D. R.

AU - Coleman, N.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs) were immunostained for desmosomal proteins and glycoproteins, and results were assessed using a semi-quantitative grading system. No difference between normal cervix and low-grade SIL (LSIL) was found. A significant reduction in expression of desmogleins was seen between high-grade SIL (HSIL) and LSIL (P

AB - We have used immunohistochemistry to test the hypothesis that components of the desmosome are disrupted during neoplastic progression of squamous epithelial cells in the uterine cervix. Sections of normal cervix and squamous intraepithelial lesions (SILs) were immunostained for desmosomal proteins and glycoproteins, and results were assessed using a semi-quantitative grading system. No difference between normal cervix and low-grade SIL (LSIL) was found. A significant reduction in expression of desmogleins was seen between high-grade SIL (HSIL) and LSIL (P

KW - Cervix

KW - Desmocollin

KW - Desmoglein

KW - Desmoplakin

KW - Desmosome

KW - Neoplasia

U2 - 10.1007/s00428-003-0771-9

DO - 10.1007/s00428-003-0771-9

M3 - Article

VL - 443

SP - 51

EP - 56

JO - Virchows Archiv

JF - Virchows Archiv

SN - 0945-6317

IS - 1

ER -

Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix

Abstract

Keywords

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