Alzheimer's disease: Insights from Drosophila melanogaster models

Aileen Moloney, David B. Sattelle, David A. Lomas, Damian C. Crowther

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The power of fruit fly genetics is being deployed against some of the most intractable and economically significant problems in modern medicine, the neurodegenerative diseases. Fly models of Alzheimer's disease can be exposed to the rich diversity of biological techniques that are available to the community and are providing new insights into disease mechanisms, and assisting in the identification of novel targets for therapy. Similar approaches might also help us to interpret the results of genome-wide association studies of human neurodegenerative diseases by allowing us to triage gene " hits" according to whether a candidate risk factor gene has a modifying effect on the disease phenotypes in fly model systems. © 2009 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)228-235
    Number of pages7
    JournalTrends in Biochemical Sciences
    Volume35
    Issue number4
    DOIs
    Publication statusPublished - Apr 2010

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