Alzheimer's disease: Insights from Drosophila melanogaster models

Aileen Moloney; David B. Sattelle; David A. Lomas; Damian C. Crowther

doi:10.1016/j.tibs.2009.11.004

Alzheimer's disease: Insights from Drosophila melanogaster models

Aileen Moloney
, David B. Sattelle
, David A. Lomas
, Damian C. Crowther

Research output: Contribution to journal › Article › peer-review

Abstract

The power of fruit fly genetics is being deployed against some of the most intractable and economically significant problems in modern medicine, the neurodegenerative diseases. Fly models of Alzheimer's disease can be exposed to the rich diversity of biological techniques that are available to the community and are providing new insights into disease mechanisms, and assisting in the identification of novel targets for therapy. Similar approaches might also help us to interpret the results of genome-wide association studies of human neurodegenerative diseases by allowing us to triage gene " hits" according to whether a candidate risk factor gene has a modifying effect on the disease phenotypes in fly model systems. © 2009 Elsevier Ltd.

Original language	English
Pages (from-to)	228-235
Number of pages	7
Journal	Trends in Biochemical Sciences
Volume	35
Issue number	4
DOIs	https://doi.org/10.1016/j.tibs.2009.11.004
Publication status	Published - Apr 2010

Access to Document

10.1016/j.tibs.2009.11.004

Cite this

@article{a7ea23b392a54def8df55584d3707008,

title = "Alzheimer's disease: Insights from Drosophila melanogaster models",

abstract = "The power of fruit fly genetics is being deployed against some of the most intractable and economically significant problems in modern medicine, the neurodegenerative diseases. Fly models of Alzheimer's disease can be exposed to the rich diversity of biological techniques that are available to the community and are providing new insights into disease mechanisms, and assisting in the identification of novel targets for therapy. Similar approaches might also help us to interpret the results of genome-wide association studies of human neurodegenerative diseases by allowing us to triage gene {"} hits{"} according to whether a candidate risk factor gene has a modifying effect on the disease phenotypes in fly model systems. {\textcopyright} 2009 Elsevier Ltd.",

author = "Aileen Moloney and Sattelle, \{David B.\} and Lomas, \{David A.\} and Crowther, \{Damian C.\}",

note = ", Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom",

year = "2010",

month = apr,

doi = "10.1016/j.tibs.2009.11.004",

language = "English",

volume = "35",

pages = "228--235",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "Elsevier BV",

number = "4",

}

TY - JOUR

T1 - Alzheimer's disease: Insights from Drosophila melanogaster models

AU - Moloney, Aileen

AU - Sattelle, David B.

AU - Lomas, David A.

AU - Crowther, Damian C.

N1 - , Medical Research Council, United Kingdom, Wellcome Trust, United Kingdom

PY - 2010/4

Y1 - 2010/4

N2 - The power of fruit fly genetics is being deployed against some of the most intractable and economically significant problems in modern medicine, the neurodegenerative diseases. Fly models of Alzheimer's disease can be exposed to the rich diversity of biological techniques that are available to the community and are providing new insights into disease mechanisms, and assisting in the identification of novel targets for therapy. Similar approaches might also help us to interpret the results of genome-wide association studies of human neurodegenerative diseases by allowing us to triage gene " hits" according to whether a candidate risk factor gene has a modifying effect on the disease phenotypes in fly model systems. © 2009 Elsevier Ltd.

AB - The power of fruit fly genetics is being deployed against some of the most intractable and economically significant problems in modern medicine, the neurodegenerative diseases. Fly models of Alzheimer's disease can be exposed to the rich diversity of biological techniques that are available to the community and are providing new insights into disease mechanisms, and assisting in the identification of novel targets for therapy. Similar approaches might also help us to interpret the results of genome-wide association studies of human neurodegenerative diseases by allowing us to triage gene " hits" according to whether a candidate risk factor gene has a modifying effect on the disease phenotypes in fly model systems. © 2009 Elsevier Ltd.

U2 - 10.1016/j.tibs.2009.11.004

DO - 10.1016/j.tibs.2009.11.004

M3 - Article

C2 - 20036556

SN - 0968-0004

VL - 35

SP - 228

EP - 235

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 4

ER -

Alzheimer's disease: Insights from Drosophila melanogaster models

Abstract

Access to Document

Fingerprint

Cite this