Amiodarone overdose and its management

C. J R Goddard, P. J. Whorwell

    Research output: Contribution to journalArticlepeer-review


    A patient taking an overdose of 3.4 g of amiodarone is described. Consciousness and physical examination remained normal throughout. Continuous electrocardiographic monitoring for 48 hours after admission revealed only a self-limiting episode of ventricular tachycardia, despite high serum levels of the drug (serum desethylamiodarone levels 4.4 mg/l). The pharmacokinetic properties of amiodarone and treatment strategies for the overdose situation are discussed. It is suggested that there may be a role for the use of cholestyramine in the treatment of both acute and chronic amiodarone toxicity.
    Original languageEnglish
    Pages (from-to)184-186
    Number of pages2
    JournalBritish Journal of Clinical Practice
    Issue number5
    Publication statusPublished - 1989


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