Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs

D. Missirlis; N. Tirelli; J. A. Hubbell

Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs

D. Missirlis, N. Tirelli, J. A. Hubbell

Research output: Chapter in Book/Conference proceeding › Conference contribution

Abstract

The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress\|Trans. World Biomater. Congr.
Pages	353
Publication status	Published - 2004
Event	Transactions - 7th World Biomaterials Congress - Sydney Duration: 1 Jul 2004 → …

Conference

Conference	Transactions - 7th World Biomaterials Congress
City	Sydney
Period	1/07/04 → …

Cite this

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title = "Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs",

abstract = "The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.",

author = "D. Missirlis and N. Tirelli and Hubbell, {J. A.}",

year = "2004",

language = "English",

isbn = "1877040193",

pages = "353",

booktitle = "Transactions - 7th World Biomaterials Congress|Trans. World Biomater. Congr.",

note = "Transactions - 7th World Biomaterials Congress ; Conference date: 01-07-2004",

}

TY - GEN

T1 - Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs

AU - Missirlis, D.

AU - Tirelli, N.

AU - Hubbell, J. A.

PY - 2004

Y1 - 2004

N2 - The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.

AB - The preparation and characterization of sub-micron hydrophilic nanoparticles with an ability to solubilize and release bioactive hydrophobic molecules in a controlled thermoset was reported. Pyrene fluorescence was studied in different nanoparticle concentrations to determine nanostructure. It was observed that the nanoparticle diameters, ranging between 50 and 500 nm, increased with the macromonomer concentration and with decreasing emulsifier content. The absorbance intensity at 490 nm of the nanoparticle suspension was used to calculate the percentage of doxorubicin (DOX) released.

M3 - Conference contribution

SN - 1877040193

SN - 9781877040191

SP - 353

BT - Transactions - 7th World Biomaterials Congress|Trans. World Biomater. Congr.

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 1 July 2004

ER -

Amphiphilic, PEG-based nanoparticles for the delivery of hydrophobic drugs

Abstract

Conference

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