Amplification of AML1 in childhood acute lymphoblastic leukemias

P Dal Cin; L Atkins; C Ford; S Ariyanayagam; S A Armstrong; R George; A Cleary; C C Morton

Amplification of AML1 in childhood acute lymphoblastic leukemias

P Dal Cin, L Atkins, C Ford, S Ariyanayagam, S A Armstrong, R George, A Cleary, C C Morton

Division of Evolution, Infection and Genomics

Brigham and Womens Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Amplification of AML1 has been confirmed by fluorescence in situ hybridization analysis in two cases of childhood acute lymphoblastic leukemia. It remains to be elucidated whether this amplification results in up-regulation of the normal AML1 gene product or a potentially mutant AML1 transcript.

Original language	English
Pages (from-to)	407-9
Number of pages	3
Journal	Genes, Chromosomes & Cancer
Volume	30
Issue number	4
Publication status	Published - Apr 2001

Keywords

Child
Chromosome Banding
Core Binding Factor Alpha 2 Subunit
DNA-Binding Proteins
Female
Gene Amplification
Humans
In Situ Hybridization, Fluorescence
Male
Neoplasm Proteins
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Proto-Oncogene Proteins
Transcription Factors
Case Reports
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Amplification of AML1 in childhood acute lymphoblastic leukemias",

abstract = "Amplification of AML1 has been confirmed by fluorescence in situ hybridization analysis in two cases of childhood acute lymphoblastic leukemia. It remains to be elucidated whether this amplification results in up-regulation of the normal AML1 gene product or a potentially mutant AML1 transcript.",

keywords = "Child, Chromosome Banding, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Female, Gene Amplification, Humans, In Situ Hybridization, Fluorescence, Male, Neoplasm Proteins, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins, Transcription Factors, Case Reports, Journal Article",

author = "{Dal Cin}, P and L Atkins and C Ford and S Ariyanayagam and Armstrong, {S A} and R George and A Cleary and Morton, {C C}",

year = "2001",

month = apr,

language = "English",

volume = "30",

pages = "407--9",

journal = "Genes, Chromosomes & Cancer",

issn = "1045-2257",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - Amplification of AML1 in childhood acute lymphoblastic leukemias

AU - Dal Cin, P

AU - Atkins, L

AU - Ford, C

AU - Ariyanayagam, S

AU - Armstrong, S A

AU - George, R

AU - Cleary, A

AU - Morton, C C

PY - 2001/4

Y1 - 2001/4

N2 - Amplification of AML1 has been confirmed by fluorescence in situ hybridization analysis in two cases of childhood acute lymphoblastic leukemia. It remains to be elucidated whether this amplification results in up-regulation of the normal AML1 gene product or a potentially mutant AML1 transcript.

AB - Amplification of AML1 has been confirmed by fluorescence in situ hybridization analysis in two cases of childhood acute lymphoblastic leukemia. It remains to be elucidated whether this amplification results in up-regulation of the normal AML1 gene product or a potentially mutant AML1 transcript.

KW - Child

KW - Chromosome Banding

KW - Core Binding Factor Alpha 2 Subunit

KW - DNA-Binding Proteins

KW - Female

KW - Gene Amplification

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Neoplasm Proteins

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Proto-Oncogene Proteins

KW - Transcription Factors

KW - Case Reports

KW - Journal Article

M3 - Article

C2 - 11241794

SN - 1045-2257

VL - 30

SP - 407

EP - 409

JO - Genes, Chromosomes & Cancer

JF - Genes, Chromosomes & Cancer

IS - 4

ER -

Amplification of AML1 in childhood acute lymphoblastic leukemias

Abstract

Keywords

UN SDGs

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