Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Iman El-Hariry, Thomas Powles, Mike R. Lau, Cora N. Sternberg, Alain Ravaud, Hans von der Maase, Niko Zantl, Peter Harper, Frédéric Rolland, Bruno Audhuy, Friederike Barthel, Jean Pascal Machiels, Pina Patel, Ernst Dietrick Kreuser, Robert E. Hawkins

    Research output: Contribution to journalArticlepeer-review


    Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC. © 2010 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)859-862
    Number of pages3
    JournalEuropean Journal of Cancer
    Issue number5
    Publication statusPublished - Mar 2010


    • Epidermal growth factor receptor
    • Fluorescent in situ hybridisation
    • Renal cell carcinoma


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