Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Iman El-Hariry; Thomas Powles; Mike R. Lau; Cora N. Sternberg; Alain Ravaud; Hans von der Maase; Niko Zantl; Peter Harper; Frédéric Rolland; Bruno Audhuy; Friederike Barthel; Jean Pascal Machiels; Pina Patel; Ernst Dietrick Kreuser; Robert E. Hawkins

doi:10.1016/j.ejca.2010.01.011

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Iman El-Hariry, Thomas Powles, Mike R. Lau, Cora N. Sternberg, Alain Ravaud, Hans von der Maase, Niko Zantl, Peter Harper, Frédéric Rolland, Bruno Audhuy, Friederike Barthel, Jean Pascal Machiels, Pina Patel, Ernst Dietrick Kreuser, Robert E. Hawkins

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC. © 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	859-862
Number of pages	3
Journal	European Journal of Cancer
Volume	46
Issue number	5
DOIs	https://doi.org/10.1016/j.ejca.2010.01.011
Publication status	Published - Mar 2010

Keywords

Epidermal growth factor receptor
Fluorescent in situ hybridisation
Renal cell carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2010.01.011

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El-Hariry, I., Powles, T., Lau, M. R., Sternberg, C. N., Ravaud, A., von der Maase, H., Zantl, N., Harper, P., Rolland, F., Audhuy, B., Barthel, F., Machiels, J. P., Patel, P., Kreuser, E. D., & Hawkins, R. E. (2010). Amplification of epidermal growth factor receptor gene in renal cell carcinoma. European Journal of Cancer, 46(5), 859-862. https://doi.org/10.1016/j.ejca.2010.01.011

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title = "Amplification of epidermal growth factor receptor gene in renal cell carcinoma",

abstract = "Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC. {\textcopyright} 2010 Elsevier Ltd. All rights reserved.",

keywords = "Epidermal growth factor receptor, Fluorescent in situ hybridisation, Renal cell carcinoma",

author = "Iman El-Hariry and Thomas Powles and Lau, {Mike R.} and Sternberg, {Cora N.} and Alain Ravaud and {von der Maase}, Hans and Niko Zantl and Peter Harper and Fr{\'e}d{\'e}ric Rolland and Bruno Audhuy and Friederike Barthel and Machiels, {Jean Pascal} and Pina Patel and Kreuser, {Ernst Dietrick} and Hawkins, {Robert E.}",

year = "2010",

month = mar,

doi = "10.1016/j.ejca.2010.01.011",

language = "English",

volume = "46",

pages = "859--862",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier BV",

number = "5",

}

El-Hariry, I, Powles, T, Lau, MR, Sternberg, CN, Ravaud, A, von der Maase, H, Zantl, N, Harper, P, Rolland, F, Audhuy, B, Barthel, F, Machiels, JP, Patel, P, Kreuser, ED & Hawkins, RE 2010, 'Amplification of epidermal growth factor receptor gene in renal cell carcinoma', European Journal of Cancer, vol. 46, no. 5, pp. 859-862. https://doi.org/10.1016/j.ejca.2010.01.011

TY - JOUR

T1 - Amplification of epidermal growth factor receptor gene in renal cell carcinoma

AU - El-Hariry, Iman

AU - Powles, Thomas

AU - Lau, Mike R.

AU - Sternberg, Cora N.

AU - Ravaud, Alain

AU - von der Maase, Hans

AU - Zantl, Niko

AU - Harper, Peter

AU - Rolland, Frédéric

AU - Audhuy, Bruno

AU - Barthel, Friederike

AU - Machiels, Jean Pascal

AU - Patel, Pina

AU - Kreuser, Ernst Dietrick

AU - Hawkins, Robert E.

PY - 2010/3

Y1 - 2010/3

N2 - Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC. © 2010 Elsevier Ltd. All rights reserved.

AB - Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC. © 2010 Elsevier Ltd. All rights reserved.

KW - Epidermal growth factor receptor

KW - Fluorescent in situ hybridisation

KW - Renal cell carcinoma

U2 - 10.1016/j.ejca.2010.01.011

DO - 10.1016/j.ejca.2010.01.011

M3 - Article

SN - 0959-8049

VL - 46

SP - 859

EP - 862

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 5

ER -

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Abstract

Keywords

UN SDGs

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