Amylin [1-3], the major peptide component of the islet amyloid  commonly found in the pancreases of patients with type 2 (non-insulin-dependent) diabetes mellitus (NIDDM) [4-6], is a recently discovered islet polypeptide. This peptide has many structural and functional features suggesting that it is a novel hormone , which may control carbohydrate metabolism in partnership with insulin and other glucoregulatory factors [2,3]. Amylin is synthesised in, and probably secreted from, the ß-cells of the islets of Langerhans [7-12], where it has recently been immunolocalised to secretory granules . DNA cloning studies indicate that in the human and the rat, amylin is generated from a precursor, preproamylin, which displays a typical signal peptide followed by a small prohormone-like sequence containing the amylin sequence [7,14-17]. The presence of the signal peptide suggests that amylin is secreted and plays a physiological role [14,16,17]. Amylin is probably generated by proteolytic processing similar to that for proinsulin and other islet prohormones. The human amylin gene encodes the complete polypeptide pre-. © 1989.
|Number of pages||11|
|Journal||Biochimica et Biophysica Acta - Molecular Cell Research|
|Publication status||Published - 14 Dec 1989|
- Amylin gene
- Diabetes mellitus