An abnormal T cell repertoire in hypergammaglobulinaemic primary Sj"gren's syndrome

R.A. Kay, E.M. Hay, P.A. Dyer, C. Dennett, L.M. Green, R.M. Bernstein, P.J. Holt, R.S. Pumphrey, A.W. Boylston, WER Ollier

    Research output: Contribution to journalArticlepeer-review


    T cell antigen specificity is determined by the products of the genes which encode the variable regions of their receptors. Of the T cell receptor (TCR) variable region gene products examined, only V beta 6.7a TCR-positive lymphocytes were reduced in primary Sjogren's syndrome patients with IgG1 hypergammaglobulinaemia compared with an age-, sex- and HLA-matched control population. The levels of V beta 6.7a T cells were also significantly reduced when these patients were compared with an age- and sex-matched but HLA-unmatched control group and non-tissue typed normal people of both sexes. Since published studies show no such abnormality in rheumatoid arthritis, systemic lupus erythematosus or other autoimmune diseases, this abnormality may reflect a pathogenic process specific to primary Sjogren's syndrome
    Original languageEnglish
    Pages (from-to)262-264
    Number of pages3
    JournalClinical and experimental immunology
    Volume85, 2
    Publication statusPublished - 1991




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