An adaptation of the Candida albicans phototoxicity test to demonstrate photosensitizer action spectra.

N. K. Gibbs

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The Candida albicans assay is widely used for the testing of potential photosensitizers, especially furocoumarins. A novel adaptation of this assay is described which provides a rapid, inexpensive and easy-to-perform method of producing action spectra. The use of filter paper rectangles with central apertures instead of the usual discs, and monochromatic irradiation with a liquid light guide reduces some of the problems associated with the standard assay. Action spectra for 8-methoxypsoralen and a new pyrrolocoumarin derivative are presented as illustrative examples.
    Original languageEnglish
    Pages (from-to)312-316
    Number of pages4
    JournalPhotodermatology
    Volume4
    Issue number6
    Publication statusPublished - Dec 1987

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