An analysis of clustering of betapapillomavirus antibodies

K. A. Mallitt; P. O'Rourke; J. N. Bouwes Bavinck; D. Abeni; M. N C De Koning; M. C W Feltkamp; A. C. Green; W. G V Quint; K. M. Michael; M. Pawlita; H. Pfister; S. Weissenborn; T. Waterboer; R. E. Neale; P. Van Der Zwan-Kralt; Y. G L De Graaf; L. E. Vos; E. J. Uphoff-Meijerink; R. Willemze; L. Struijk; P. Wanningen; P. Z. Van Der Meijden; E. I. Plasmeijer; R. Wolterbeek; S. Euvrard; A. C. Butnaru; A. Claudy; J. Kanitakis; I. Nindl; E. Stockfleth; T. Forschner; L. Naldi; A. Pizzagalli; F. Sassi; G. Tessari; C. A. Harwood; C. M. Proby; J. Breuer; L. Mitchell; K. Purdie; S. R. Lambert; H. Ran; U. Wieland; P. Sehr; J. Ter Schegget; B. Kleter; L. J. Van Doorn; F. Sampogna; T. J. Mannooranparampil; N. Melo-Salcedo; S. Simoni; G. P. Petasecca Donati; C. Masini; C. Deppermann Fortes; C. Olsen; S. Harrison; P. Buttner

doi:10.1099/vir.0.017970-0

An analysis of clustering of betapapillomavirus antibodies

K. A. Mallitt, P. O'Rourke, J. N. Bouwes Bavinck, D. Abeni, M. N C De Koning, M. C W Feltkamp, A. C. Green, W. G V Quint, K. M. Michael, M. Pawlita, H. Pfister, S. Weissenborn, T. Waterboer, R. E. Neale, P. Van Der Zwan-Kralt, Y. G L De Graaf, L. E. Vos, E. J. Uphoff-Meijerink, R. Willemze, L. StruijkP. Wanningen, P. Z. Van Der Meijden, E. I. Plasmeijer, R. Wolterbeek, S. Euvrard, A. C. Butnaru, A. Claudy, J. Kanitakis, I. Nindl, E. Stockfleth, T. Forschner, L. Naldi, A. Pizzagalli, F. Sassi, G. Tessari, C. A. Harwood, C. M. Proby, J. Breuer, L. Mitchell, K. Purdie, S. R. Lambert, H. Ran, U. Wieland, P. Sehr, J. Ter Schegget, B. Kleter, L. J. Van Doorn, F. Sampogna, T. J. Mannooranparampil, N. Melo-Salcedo, S. Simoni, G. P. Petasecca Donati, C. Masini, C. Deppermann Fortes, C. Olsen, S. Harrison, P. Buttner

Research output: Contribution to journal › Article › peer-review

Abstract

Betapapillomaviruses (βPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This study aimed to determine whether specific virus types were more likely to co-occur than others, thereby reducing the number of parameters needed in statistical models. Antibody data were analysed from controls who participated in case-control studies in The Netherlands, Italy and Australia and from participants in the German Nutrition Survey. Cluster analysis and two ordination techniques were used to identify patterns. Evidence of clustering was found only according to the number of viruses to which antibodies were detected. The lack of clustering of specific viral types identified suggests that if there are βPV types that are independently related to skin carcinogenesis, they are unlikely to be identified using standard epidemiological methods. © 2010 SGM.

Original language	English
Pages (from-to)	2062-2067
Number of pages	5
Journal	Journal of General Virology
Volume	91
Issue number	8
DOIs	https://doi.org/10.1099/vir.0.017970-0
Publication status	Published - Aug 2010

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http://vir.sgmjournals.org/cgi/reprint/91/8/2062

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Mallitt, K. A., O'Rourke, P., Bouwes Bavinck, J. N., Abeni, D., De Koning, M. N. C., Feltkamp, M. C. W., Green, A. C., Quint, W. G. V., Michael, K. M., Pawlita, M., Pfister, H., Weissenborn, S., Waterboer, T., Neale, R. E., Van Der Zwan-Kralt, P., De Graaf, Y. G. L., Vos, L. E., Uphoff-Meijerink, E. J., Willemze, R., ... Buttner, P. (2010). An analysis of clustering of betapapillomavirus antibodies. Journal of General Virology, 91(8), 2062-2067. https://doi.org/10.1099/vir.0.017970-0

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title = "An analysis of clustering of betapapillomavirus antibodies",

abstract = "Betapapillomaviruses (βPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This study aimed to determine whether specific virus types were more likely to co-occur than others, thereby reducing the number of parameters needed in statistical models. Antibody data were analysed from controls who participated in case-control studies in The Netherlands, Italy and Australia and from participants in the German Nutrition Survey. Cluster analysis and two ordination techniques were used to identify patterns. Evidence of clustering was found only according to the number of viruses to which antibodies were detected. The lack of clustering of specific viral types identified suggests that if there are βPV types that are independently related to skin carcinogenesis, they are unlikely to be identified using standard epidemiological methods. {\textcopyright} 2010 SGM.",

author = "Mallitt, {K. A.} and P. O'Rourke and {Bouwes Bavinck}, {J. N.} and D. Abeni and {De Koning}, {M. N C} and Feltkamp, {M. C W} and Green, {A. C.} and Quint, {W. G V} and Michael, {K. M.} and M. Pawlita and H. Pfister and S. Weissenborn and T. Waterboer and Neale, {R. E.} and {Van Der Zwan-Kralt}, P. and {De Graaf}, {Y. G L} and Vos, {L. E.} and Uphoff-Meijerink, {E. J.} and R. Willemze and L. Struijk and P. Wanningen and {Van Der Meijden}, {P. Z.} and Plasmeijer, {E. I.} and R. Wolterbeek and S. Euvrard and Butnaru, {A. C.} and A. Claudy and J. Kanitakis and I. Nindl and E. Stockfleth and T. Forschner and L. Naldi and A. Pizzagalli and F. Sassi and G. Tessari and Harwood, {C. A.} and Proby, {C. M.} and J. Breuer and L. Mitchell and K. Purdie and Lambert, {S. R.} and H. Ran and U. Wieland and P. Sehr and {Ter Schegget}, J. and B. Kleter and {Van Doorn}, {L. J.} and F. Sampogna and Mannooranparampil, {T. J.} and N. Melo-Salcedo and S. Simoni and {Petasecca Donati}, {G. P.} and C. Masini and {Deppermann Fortes}, C. and C. Olsen and S. Harrison and P. Buttner",

year = "2010",

month = aug,

doi = "10.1099/vir.0.017970-0",

language = "English",

volume = "91",

pages = "2062--2067",

journal = "Journal of General Virology",

issn = "1465-2099",

publisher = "Microbiology Society",

number = "8",

}

Mallitt, KA, O'Rourke, P, Bouwes Bavinck, JN, Abeni, D, De Koning, MNC, Feltkamp, MCW, Green, AC, Quint, WGV, Michael, KM, Pawlita, M, Pfister, H, Weissenborn, S, Waterboer, T, Neale, RE, Van Der Zwan-Kralt, P, De Graaf, YGL, Vos, LE, Uphoff-Meijerink, EJ, Willemze, R, Struijk, L, Wanningen, P, Van Der Meijden, PZ, Plasmeijer, EI, Wolterbeek, R, Euvrard, S, Butnaru, AC, Claudy, A, Kanitakis, J, Nindl, I, Stockfleth, E, Forschner, T, Naldi, L, Pizzagalli, A, Sassi, F, Tessari, G, Harwood, CA, Proby, CM, Breuer, J, Mitchell, L, Purdie, K, Lambert, SR, Ran, H, Wieland, U, Sehr, P, Ter Schegget, J, Kleter, B, Van Doorn, LJ, Sampogna, F, Mannooranparampil, TJ, Melo-Salcedo, N, Simoni, S, Petasecca Donati, GP, Masini, C, Deppermann Fortes, C, Olsen, C, Harrison, S & Buttner, P 2010, 'An analysis of clustering of betapapillomavirus antibodies', Journal of General Virology, vol. 91, no. 8, pp. 2062-2067. https://doi.org/10.1099/vir.0.017970-0

TY - JOUR

T1 - An analysis of clustering of betapapillomavirus antibodies

AU - Mallitt, K. A.

AU - O'Rourke, P.

AU - Bouwes Bavinck, J. N.

AU - Abeni, D.

AU - De Koning, M. N C

AU - Feltkamp, M. C W

AU - Green, A. C.

AU - Quint, W. G V

AU - Michael, K. M.

AU - Pawlita, M.

AU - Pfister, H.

AU - Weissenborn, S.

AU - Waterboer, T.

AU - Neale, R. E.

AU - Van Der Zwan-Kralt, P.

AU - De Graaf, Y. G L

AU - Vos, L. E.

AU - Uphoff-Meijerink, E. J.

AU - Willemze, R.

AU - Struijk, L.

AU - Wanningen, P.

AU - Van Der Meijden, P. Z.

AU - Plasmeijer, E. I.

AU - Wolterbeek, R.

AU - Euvrard, S.

AU - Butnaru, A. C.

AU - Claudy, A.

AU - Kanitakis, J.

AU - Nindl, I.

AU - Stockfleth, E.

AU - Forschner, T.

AU - Naldi, L.

AU - Pizzagalli, A.

AU - Sassi, F.

AU - Tessari, G.

AU - Harwood, C. A.

AU - Proby, C. M.

AU - Breuer, J.

AU - Mitchell, L.

AU - Purdie, K.

AU - Lambert, S. R.

AU - Ran, H.

AU - Wieland, U.

AU - Sehr, P.

AU - Ter Schegget, J.

AU - Kleter, B.

AU - Van Doorn, L. J.

AU - Sampogna, F.

AU - Mannooranparampil, T. J.

AU - Melo-Salcedo, N.

AU - Simoni, S.

AU - Petasecca Donati, G. P.

AU - Masini, C.

AU - Deppermann Fortes, C.

AU - Olsen, C.

AU - Harrison, S.

AU - Buttner, P.

PY - 2010/8

Y1 - 2010/8

N2 - Betapapillomaviruses (βPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This study aimed to determine whether specific virus types were more likely to co-occur than others, thereby reducing the number of parameters needed in statistical models. Antibody data were analysed from controls who participated in case-control studies in The Netherlands, Italy and Australia and from participants in the German Nutrition Survey. Cluster analysis and two ordination techniques were used to identify patterns. Evidence of clustering was found only according to the number of viruses to which antibodies were detected. The lack of clustering of specific viral types identified suggests that if there are βPV types that are independently related to skin carcinogenesis, they are unlikely to be identified using standard epidemiological methods. © 2010 SGM.

AB - Betapapillomaviruses (βPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This study aimed to determine whether specific virus types were more likely to co-occur than others, thereby reducing the number of parameters needed in statistical models. Antibody data were analysed from controls who participated in case-control studies in The Netherlands, Italy and Australia and from participants in the German Nutrition Survey. Cluster analysis and two ordination techniques were used to identify patterns. Evidence of clustering was found only according to the number of viruses to which antibodies were detected. The lack of clustering of specific viral types identified suggests that if there are βPV types that are independently related to skin carcinogenesis, they are unlikely to be identified using standard epidemiological methods. © 2010 SGM.

U2 - 10.1099/vir.0.017970-0

DO - 10.1099/vir.0.017970-0

M3 - Article

C2 - 20392895

SN - 1465-2099

VL - 91

SP - 2062

EP - 2067

JO - Journal of General Virology

JF - Journal of General Virology

IS - 8

ER -

An analysis of clustering of betapapillomavirus antibodies

Abstract

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