An analytic dosimetry study for the use of radionuclide liposome conjugates in internal radiotherapy

D Emfietzoglou; Kostas Kostarelos; G Sgouros

An analytic dosimetry study for the use of radionuclide liposome conjugates in internal radiotherapy

D Emfietzoglou, Kostas Kostarelos, G Sgouros

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

A dosimetric analysis has been performed to evaluate the potential of liposome systems as carriers of radionuclides in internal radiotherapy. Methods: Pharmacokinetic data for a variety of liposome constructs (multilamellar vesicles [MLV]; small unilamellar vesicles [SUV]; and sterically stabilized liposomes, monosialoganglioside [GM1]-coated) were used to obtain tumor and normal-organ absorbed dose estimates for 67Cu, 188Re, 90Y, and 131I.

Original language	English
Pages (from-to)	499-504
Journal	The journal of Nuclear Medicine
Volume	42
Issue number	3
Publication status	Published - 2001

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title = "An analytic dosimetry study for the use of radionuclide liposome conjugates in internal radiotherapy",

abstract = "A dosimetric analysis has been performed to evaluate the potential of liposome systems as carriers of radionuclides in internal radiotherapy. Methods: Pharmacokinetic data for a variety of liposome constructs (multilamellar vesicles [MLV]; small unilamellar vesicles [SUV]; and sterically stabilized liposomes, monosialoganglioside [GM1]-coated) were used to obtain tumor and normal-organ absorbed dose estimates for 67Cu, 188Re, 90Y, and 131I.",

author = "D Emfietzoglou and Kostas Kostarelos and G Sgouros",

year = "2001",

language = "English",

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AU - Emfietzoglou, D

AU - Kostarelos, Kostas

AU - Sgouros, G

PY - 2001

Y1 - 2001

N2 - A dosimetric analysis has been performed to evaluate the potential of liposome systems as carriers of radionuclides in internal radiotherapy. Methods: Pharmacokinetic data for a variety of liposome constructs (multilamellar vesicles [MLV]; small unilamellar vesicles [SUV]; and sterically stabilized liposomes, monosialoganglioside [GM1]-coated) were used to obtain tumor and normal-organ absorbed dose estimates for 67Cu, 188Re, 90Y, and 131I.

AB - A dosimetric analysis has been performed to evaluate the potential of liposome systems as carriers of radionuclides in internal radiotherapy. Methods: Pharmacokinetic data for a variety of liposome constructs (multilamellar vesicles [MLV]; small unilamellar vesicles [SUV]; and sterically stabilized liposomes, monosialoganglioside [GM1]-coated) were used to obtain tumor and normal-organ absorbed dose estimates for 67Cu, 188Re, 90Y, and 131I.

M3 - Article

SN - 0161-5505

VL - 42

SP - 499

EP - 504

JO - The journal of Nuclear Medicine

JF - The journal of Nuclear Medicine

IS - 3

ER -

An analytic dosimetry study for the use of radionuclide liposome conjugates in internal radiotherapy

Abstract

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