An analytical perspective on favoured synthetic routes to the psychoactive tryptamines

Simon D. Brandt, Sally Freeman, Peter McGagh, Norliza Abdul-Halim, John F. Alder

    Research output: Contribution to journalArticlepeer-review


    Many tryptamine derivatives are known to induce altered states of consciousness and are increasingly of interest in forensic and neurobiological studies. The analytical chemistry of certain synthetic routes to the tryptamines is discussed and likely side products and impurities identified, where literature reports are available. Recent examples from the authors' laboratory are presented to highlight future prospects and implications for analytical procedures. The aim of this review is to provide the analytical chemist with the foundation chemistry and some analytical targets to be able to undertake direct characterisation of products and intermediates. These might become available from interdiction of clandestine operations in a forensic environment or during the synthesis of the tryptamines for investigative neurobiological and clinical procedures. © 2004 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)675-691
    Number of pages16
    JournalJournal of Pharmaceutical and Biomedical Analysis
    Issue number4
    Publication statusPublished - 19 Nov 2004


    • Analytical chemistry
    • Forensic studies
    • Neurobiological procedures
    • Tryptamines


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