An anterior-posterior gradient of cognitive control within the dorsomedial striatum

Anna Mestres-Missé, Robert Turner, Angela D. Friederici

    Research output: Contribution to journalArticlepeer-review


    Lateral prefrontal cortex and basal ganglia work together to mediate working memory and top-down regulation of cognition. This circuit regulates the balance and interactions between automatic and high-order control responses. Using ultra-high-field high-resolution functional magnetic resonance imaging (7. T-fMRI), the present study examined the role of subcortical structures in cognitive control during language processing. Participants were asked to judge the grammaticality of unambiguous, ungrammatical and ambiguous sentences. Grammatical unambiguous sentences should elicit an automatic response, while ambiguous and ungrammatical sentences should conflict with the automatic response and, hence, require a high-order control response. Within the control response domain, ambiguity and ungrammaticality represent two different dimensions of conflict resolution, while for a temporarily ambiguous sentence a correct interpretation is available, that is not the case for ungrammatical sentences. Our results reveal an anterior-posterior axis in the dorsomedial striatum with more rostral regions supporting higher levels of cognitive processing. This functional architecture mirrors the rostrocaudal hierarchical organization evidenced within the lateral prefrontal cortex. © 2012 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)41-47
    Number of pages6
    Issue number1
    Publication statusPublished - 1 Aug 2012


    • 7T
    • Basal ganglia
    • Caudate nucleus
    • Cognitive control
    • FMRI


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