An electric-field responsive microsystem for controllable miniaturised drug delivery applications

Y. Liu; A. Servant; O. J. Guy; Khuloud T. Al-Jamal; P. R. Williams; K. M. Hawkins; K. Kostarelos

doi:10.1016/j.snb.2011.12.069

An electric-field responsive microsystem for controllable miniaturised drug delivery applications

Y. Liu, A. Servant, O. J. Guy, Khuloud T. Al-Jamal, P. R. Williams, K. M. Hawkins, K. Kostarelos

Research output: Contribution to journal › Article › peer-review

Abstract

A novel MEMS based drug delivery device has been developed, consisting of an array of metallic contacts on silicon and Pyrex glass wafers. The meander structured device creates a uniform electric field which stimulates drug release. An electro-active hydrogel based polymer matrix has also been developed, which responds to an electrical stimulus and shrinks or de-swells on application of an electric field from the fabricated device. Different drug candidates can be encapsulated within the polymer matrix. The de-swelling of the polymer enables the encapsulated drug to be released from the matrix. The gel is able to recover its original size once electric stimulation is ceased. By controlling the applied voltage and its duration, the drug release rate and dose can be precisely controlled. Controlled drug delivery devices may be integrated with sensor technology in combined diagnostic/therapeutic point of care devices. © 2012 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	100-105
Number of pages	5
Journal	Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers
Volume	175
DOIs	https://doi.org/10.1016/j.snb.2011.12.069
Publication status	Published - Dec 2012

Keywords

Drug delivery
Electric-field responsive
Electro-active hydrogel
Point of care

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10.1016/j.snb.2011.12.069

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Liu, Y., Servant, A., Guy, O. J., Al-Jamal, K. T., Williams, P. R., Hawkins, K. M., & Kostarelos, K. (2012). An electric-field responsive microsystem for controllable miniaturised drug delivery applications. Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 175, 100-105. https://doi.org/10.1016/j.snb.2011.12.069

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abstract = "A novel MEMS based drug delivery device has been developed, consisting of an array of metallic contacts on silicon and Pyrex glass wafers. The meander structured device creates a uniform electric field which stimulates drug release. An electro-active hydrogel based polymer matrix has also been developed, which responds to an electrical stimulus and shrinks or de-swells on application of an electric field from the fabricated device. Different drug candidates can be encapsulated within the polymer matrix. The de-swelling of the polymer enables the encapsulated drug to be released from the matrix. The gel is able to recover its original size once electric stimulation is ceased. By controlling the applied voltage and its duration, the drug release rate and dose can be precisely controlled. Controlled drug delivery devices may be integrated with sensor technology in combined diagnostic/therapeutic point of care devices. {\textcopyright} 2012 Elsevier B.V. All rights reserved.",

keywords = "Drug delivery, Electric-field responsive, Electro-active hydrogel, Point of care",

author = "Y. Liu and A. Servant and Guy, {O. J.} and Al-Jamal, {Khuloud T.} and Williams, {P. R.} and Hawkins, {K. M.} and K. Kostarelos",

note = "Times Cited: 0 SI 25th Eurosensors Conference SEP 04-07, 2011 Athens, GREECE 0",

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Liu, Y, Servant, A, Guy, OJ, Al-Jamal, KT, Williams, PR, Hawkins, KM & Kostarelos, K 2012, 'An electric-field responsive microsystem for controllable miniaturised drug delivery applications', Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, vol. 175, pp. 100-105. https://doi.org/10.1016/j.snb.2011.12.069

An electric-field responsive microsystem for controllable miniaturised drug delivery applications. / Liu, Y.; Servant, A.; Guy, O. J. et al.
In: Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, Vol. 175, 12.2012, p. 100-105.

Research output: Contribution to journal › Article › peer-review

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AU - Servant, A.

AU - Guy, O. J.

AU - Al-Jamal, Khuloud T.

AU - Williams, P. R.

AU - Hawkins, K. M.

AU - Kostarelos, K.

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AB - A novel MEMS based drug delivery device has been developed, consisting of an array of metallic contacts on silicon and Pyrex glass wafers. The meander structured device creates a uniform electric field which stimulates drug release. An electro-active hydrogel based polymer matrix has also been developed, which responds to an electrical stimulus and shrinks or de-swells on application of an electric field from the fabricated device. Different drug candidates can be encapsulated within the polymer matrix. The de-swelling of the polymer enables the encapsulated drug to be released from the matrix. The gel is able to recover its original size once electric stimulation is ceased. By controlling the applied voltage and its duration, the drug release rate and dose can be precisely controlled. Controlled drug delivery devices may be integrated with sensor technology in combined diagnostic/therapeutic point of care devices. © 2012 Elsevier B.V. All rights reserved.

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KW - Electro-active hydrogel

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JF - Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers

ER -

An electric-field responsive microsystem for controllable miniaturised drug delivery applications

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Keywords

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