An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head

Kimberly A. Mace, Joseph C. Pearson, William McGinnis

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier.
    Original languageEnglish
    Pages (from-to)381-385
    Number of pages4
    JournalScience
    Volume308
    Issue number5720
    DOIs
    Publication statusPublished - 15 Apr 2005

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