An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

A.R. Butler, R.A. Field, I.R. Greig, F.W. Flitney, S.K. Bisland, F. Khan, J.J.F. Belch

Research output: Contribution to journalArticlepeer-review

Abstract

A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
Original languageUndefined
Pages (from-to)211-217
Number of pages7
JournalNitric Oxide - Biology and Chemistry
Volume1
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Arteries
  • drug effects
  • Carbohydrates
  • In Vitro Techniques
  • Nitroso Compounds
  • Vasodilator Agents

Research Beacons, Institutes and Platforms

  • Manchester Institute of Biotechnology

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