An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

A.R. Butler; R.A. Field; I.R. Greig; F.W. Flitney; S.K. Bisland; F. Khan; J.J.F. Belch

doi:10.1006/niox.1997.0125

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

A.R. Butler, R.A. Field, I.R. Greig, F.W. Flitney, S.K. Bisland, F. Khan, J.J.F. Belch

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

Original language	Undefined
Pages (from-to)	211-217
Number of pages	7
Journal	Nitric Oxide - Biology and Chemistry
Volume	1
Issue number	3
DOIs	https://doi.org/10.1006/niox.1997.0125
Publication status	Published - 1997

Keywords

Arteries
drug effects
Carbohydrates
In Vitro Techniques
Nitroso Compounds
Vasodilator Agents

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/niox.1997.0125

Cite this

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AU - Butler, A.R.

AU - Field, R.A.

AU - Greig, I.R.

AU - Flitney, F.W.

AU - Bisland, S.K.

AU - Khan, F.

AU - Belch, J.J.F.

PY - 1997

Y1 - 1997

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AB - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.

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KW - drug effects

KW - Carbohydrates

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KW - Nitroso Compounds

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JO - Nitric Oxide - Biology and Chemistry

JF - Nitric Oxide - Biology and Chemistry

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ER -

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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