An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis: The intervention to encourage activity, improve diet, and reduce weight gain (INTERACT) study

Karina Lovell, Alison Wearden, Tim Bradshaw, Barbara Tomenson, Rebecca Pedley, Linda M. Davies, Nusrat Husain, Adrine Woodham, Diane Escott, Caroline M. Swarbrick, Omolade Femi-Ajao, Jeff Warburton, Max Marshall

Research output: Contribution to journalArticlepeer-review

62 Downloads (Pure)

Abstract

Background: People with psychosis often experience weight gain, which places them at risk of cardiovascular disease, diabetes, and early death. Objective: To determine the uptake, adherence, and clinical effectiveness of a healthy living intervention designed to reduce weight gain. Method: An exploratory randomized controlled trial, comparing the intervention with treatment as usual (TAU) in 2 early intervention services for psychosis in England. DSM-IV classification was the diagnostic criteria used to assign the psychiatric diagnoses. The primary outcome was change in body mass index (BMI) from baseline to 12-month follow-up. The study was conducted between February 2009 and October 2012. Results: 105 service users, with a BMI of ≥ 25 (≥ 24 in South Asians), were randomized to intervention (n = 54) orTAU (n = 51) after stratification by recent commencement of antipsychotic medication. Ninety-three service users (89%) were followed up at 12 months. Between-group difference in change in BMI was not significant (effect size = 0.11).The effect of the intervention was larger (effect size = 0.54, not significant) in 15 intervention (28%) and 10TAU (20%) participants who were taking olanzapine or clozapine at randomization. Conclusions: The healthy living intervention did not show a significant difference in BMI reduction compared to the TAU group. © Copyright 2014 Physicians Postgraduate Press, Inc.
Original languageEnglish
Article number24500028
Pages (from-to)498-505
Number of pages7
JournalJournal of Clinical Psychiatry
Volume75
Issue number5
DOIs
Publication statusPublished - May 2014

Fingerprint

Dive into the research topics of 'An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis: The intervention to encourage activity, improve diet, and reduce weight gain (INTERACT) study'. Together they form a unique fingerprint.

Cite this