An identifiability analysis of a parent-metabolite pharmacokinetic model for ivabradine

N. D. Adams, K. R. Godfrey, M. J. Chapman, M. J. Chappell, L. Aarons, S. B. Duffull

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The paper considers the structural identifiability of a parent-metabolite pharmacokinetic model for ivabradine and one of its metabolites. The model, which is linear, is considered initially for intravenous administration of ivabradine, and then for a combined intravenous and oral administration. In both cases, the model is shown to be unidentifiable. Simplification of the model (for both forms of administration) to that proposed by Duffull et al. (1) results in a globally structurally identifiable model. The analysis could be applied to the modeling of any drug undergoing first-pass metabolism, with plasma concentrations available from drug and metabolite.
    Original languageEnglish
    Pages (from-to)93-105
    Number of pages12
    JournalJournal of pharmacokinetics and pharmacodynamics
    Volume28
    Issue number1
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Compartmental models
    • Identification
    • Ivabradine
    • Linear systems
    • Pharmacokinetics

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