An improved model of the Aspergillus fumigatus CYP51A protein

M. G. Fraczek; M. Bromley; P. Bowyer

doi:10.1128/AAC.01651-10

An improved model of the Aspergillus fumigatus CYP51A protein

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Abstract

Azole resistance is an increasing clinical problem for Aspergillus fumigatus, with the majority of published resistance arising from mutations in the azole target gene CYP51A. Previous structural studies of this protein have suffered from a nonorthologous, low-homology template for homology modeling. Here we present a new model based on the human CYP51A orthologue that provides a higher-quality model for A. fumigatus CYP51A. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	2483-2486
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01651-10
Publication status	Published - May 2011

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10.1128/AAC.01651-10

http://aac.asm.org/cgi/reprint/55/5/2483

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title = "An improved model of the Aspergillus fumigatus CYP51A protein",

abstract = "Azole resistance is an increasing clinical problem for Aspergillus fumigatus, with the majority of published resistance arising from mutations in the azole target gene CYP51A. Previous structural studies of this protein have suffered from a nonorthologous, low-homology template for homology modeling. Here we present a new model based on the human CYP51A orthologue that provides a higher-quality model for A. fumigatus CYP51A. Copyright {\textcopyright} 2011, American Society for Microbiology. All Rights Reserved.",

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AB - Azole resistance is an increasing clinical problem for Aspergillus fumigatus, with the majority of published resistance arising from mutations in the azole target gene CYP51A. Previous structural studies of this protein have suffered from a nonorthologous, low-homology template for homology modeling. Here we present a new model based on the human CYP51A orthologue that provides a higher-quality model for A. fumigatus CYP51A. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

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DO - 10.1128/AAC.01651-10

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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An improved model of the Aspergillus fumigatus CYP51A protein

Abstract

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