An in vitro comparison of dentifrice formulations in three distinct oral microbiotas.

Ruth G Ledder; Andrew J McBain

doi:10.1016/j.archoralbio.2011.08.004

An in vitro comparison of dentifrice formulations in three distinct oral microbiotas.

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: In vitro biofilm models, representative of some aspects of nascent, supra-gingival plaques (Hydroxyapatite Disc Biofilm Models), developed supra-gingival plaques (Modified Drip-flow Biofilm Reactors) and sub-gingival plaques (Multiple Sorbarod Devices) were used to compare the antimicrobial effects of a triclosan-containing dentifrice with a stannous fluoride and zinc lactate combination. DESIGN: Triplicate salivary biofilm microcosms were maintained for 2d (hydroxyapatite discs), 5d (Sorbarods) or up to 6d (drip flow reactors). Dentifrice slurries (10%, w/v) were added once to the discs and repeatedly to the Drip Flow Reactors and Sorbarods. Plaques were analysed by differential culture and gravimetrically. RESULTS: Whilst both dentifrices were comparably effective at reducing viability and plaque accumulation in mature supragingival plaques, the triclosan dentifrice produced comparatively larger reductions in total streptococci and anaerobes in nascent plaques (p

Original language	English
Pages (from-to)	139-147
Number of pages	8
Journal	Archives of oral biology
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/j.archoralbio.2011.08.004
Publication status	Published - Feb 2012

Keywords

Dental plaque
Dentifrice
Drip flow reactor
Hydroxyapatite biofilm reactor
Multiple sorbarod device

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10.1016/j.archoralbio.2011.08.004

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title = "An in vitro comparison of dentifrice formulations in three distinct oral microbiotas.",

abstract = "OBJECTIVES: In vitro biofilm models, representative of some aspects of nascent, supra-gingival plaques (Hydroxyapatite Disc Biofilm Models), developed supra-gingival plaques (Modified Drip-flow Biofilm Reactors) and sub-gingival plaques (Multiple Sorbarod Devices) were used to compare the antimicrobial effects of a triclosan-containing dentifrice with a stannous fluoride and zinc lactate combination. DESIGN: Triplicate salivary biofilm microcosms were maintained for 2d (hydroxyapatite discs), 5d (Sorbarods) or up to 6d (drip flow reactors). Dentifrice slurries (10%, w/v) were added once to the discs and repeatedly to the Drip Flow Reactors and Sorbarods. Plaques were analysed by differential culture and gravimetrically. RESULTS: Whilst both dentifrices were comparably effective at reducing viability and plaque accumulation in mature supragingival plaques, the triclosan dentifrice produced comparatively larger reductions in total streptococci and anaerobes in nascent plaques (p",

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AU - McBain, Andrew J

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AB - OBJECTIVES: In vitro biofilm models, representative of some aspects of nascent, supra-gingival plaques (Hydroxyapatite Disc Biofilm Models), developed supra-gingival plaques (Modified Drip-flow Biofilm Reactors) and sub-gingival plaques (Multiple Sorbarod Devices) were used to compare the antimicrobial effects of a triclosan-containing dentifrice with a stannous fluoride and zinc lactate combination. DESIGN: Triplicate salivary biofilm microcosms were maintained for 2d (hydroxyapatite discs), 5d (Sorbarods) or up to 6d (drip flow reactors). Dentifrice slurries (10%, w/v) were added once to the discs and repeatedly to the Drip Flow Reactors and Sorbarods. Plaques were analysed by differential culture and gravimetrically. RESULTS: Whilst both dentifrices were comparably effective at reducing viability and plaque accumulation in mature supragingival plaques, the triclosan dentifrice produced comparatively larger reductions in total streptococci and anaerobes in nascent plaques (p

KW - Dental plaque

KW - Dentifrice

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KW - Hydroxyapatite biofilm reactor

KW - Multiple sorbarod device

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JF - Archives of oral biology

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An in vitro comparison of dentifrice formulations in three distinct oral microbiotas.

Abstract

Keywords

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