An insight into the early mechanisms of allergen-specific immunotherapy

Dimitris I. Mitsias, Savvas Savvatianos, Nikolaos G. Papadopoulos

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Evaluation of: Bussmann C, Xia J, Allam J-P, Maintz L, Bieber T, Novak N: Early markers for protective mechanisms during rush venom immunotherapy. Allergy 65, 1558-1565 (2010). The mechanisms governing the induction of peripheral tolerance as a result of specific immunotherapy are far from being clearly characterized. In the last 15 years, a number of studies have highlighted the tolerogenic role of regulatory T cells, blocking antibodies and anti-inflammatory cytokines such as IL-10 and TGF-β; however, the best part of our knowledge is mostly limited to mechanisms underlying the maintenance phase. By contrast, little is known regarding the very early effects seen in rush and ultrarush immunotherapy protocols. In this article, Bussmann et al. provide evidence on the possible role, first, of inhibitory receptors of the leukocyte immunoglobulin-like receptor family and, second, of the upregulation of indoleamine 2,3-dioxygenase and subsequent tryptophan starvation on the induction of specific tolerance within a few hours after the initial doses. They also suggest that the observed changes reflect the activation of protective mechanisms, which we are just beginning to understand. © 2011 Future Medicine Ltd.
    Original languageEnglish
    Pages (from-to)333-336
    Number of pages3
    JournalImmunotherapy
    Volume3
    Issue number3
    DOIs
    Publication statusPublished - Mar 2011

    Keywords

    • allergen-specific immunotherapy
    • apoptosis
    • desensitization
    • IDO
    • indoleamine 2,3-dioxygenase
    • inhibitory receptor
    • leukocyte immunoglobulin-like receptor
    • LILR
    • rush protocol
    • tolerance
    • tryptophan starvation
    • venom

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