An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.

F R Ali; A Barton; R L I Smith; J Bowes; E Flynn; M Mangino; V Bataille; J P Foerster; J Worthington; C E M Griffiths; R B Warren

doi:10.1111/bjd.12106

An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.

F R Ali, A Barton, R L I Smith, J Bowes, E Flynn, M Mangino, V Bataille, J P Foerster, J Worthington, C E M Griffiths, R B Warren

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. OBJECTIVES: By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. METHODS: We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. RESULTS: Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. CONCLUSION: Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

Original language	English
Pages (from-to)	864-866
Number of pages	2
Journal	The British journal of dermatology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1111/bjd.12106
Publication status	Published - Apr 2013

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Ali, F. R., Barton, A., Smith, R. L. I., Bowes, J., Flynn, E., Mangino, M., Bataille, V., Foerster, J. P., Worthington, J., Griffiths, C. E. M., & Warren, R. B. (2013). An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene. The British journal of dermatology, 168(4), 864-866. https://doi.org/10.1111/bjd.12106

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title = "An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.",

abstract = "BACKGROUND: Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. OBJECTIVES: By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. METHODS: We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. RESULTS: Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. CONCLUSION: Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.",

author = "Ali, {F R} and A Barton and Smith, {R L I} and J Bowes and E Flynn and M Mangino and V Bataille and Foerster, {J P} and J Worthington and Griffiths, {C E M} and Warren, {R B}",

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doi = "10.1111/bjd.12106",

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T1 - An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.

AU - Ali, F R

AU - Barton, A

AU - Smith, R L I

AU - Bowes, J

AU - Flynn, E

AU - Mangino, M

AU - Bataille, V

AU - Foerster, J P

AU - Worthington, J

AU - Griffiths, C E M

AU - Warren, R B

N1 - 17552., Arthritis Research UK, United Kingdom, Medical Research Council, United Kingdom

PY - 2013/4

Y1 - 2013/4

N2 - BACKGROUND: Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. OBJECTIVES: By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. METHODS: We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. RESULTS: Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. CONCLUSION: Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

AB - BACKGROUND: Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways. OBJECTIVES: By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis. METHODS: We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects. RESULTS: Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA. CONCLUSION: Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

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DO - 10.1111/bjd.12106

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VL - 168

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EP - 866

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 4

ER -

An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.

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