An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity

Pharmacology, Toxicology and Pharmaceutical Science

• Antibiotics 100%
• Lysine 100%
• Chloride Ion 100%
• Carbapenemase 100%
• Mutagenesis 50%
• Lactam 50%
• Calorimetry 50%
• Pharmacokinetics 50%
• Acetic Acid Derivative 50%
• Antibiotic Agent 50%
• Halide 50%
• Arginine 50%
• Penicillinase 50%

Biochemistry, Genetics and Molecular Biology

• Lysine 100%
• Enzyme Catalysis 50%
• Mutagenesis 50%
• Catalytic Mechanism 50%
• Active Site 50%
• Arginine 50%
• Pharmacokinetics 50%
• Isothermal Titration Calorimetry 50%
• Steady State 50%

Immunology and Microbiology

• Enterobacterales 100%
• Mutagenesis 100%
• Pharmacokinetics 100%
• Steady State 100%