An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase

Egor P Tchesnokov, Abayomi Faponle, C. G. Davies, M. G. Quesne, R. Turner, Matthias Fellner, R. J. Souness, Sigurd M Wilbanks, Samuel De Visser, Guy N L Jameson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.

    Original languageEnglish
    Pages (from-to)8814-8817
    Number of pages4
    JournalChemical Communications
    Volume52
    Issue number57
    DOIs
    Publication statusPublished - 9 Jun 2016

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