Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method’s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.
|Publication status||Published - 11 May 2019|
|Event||ISMRM 27th Annual Meeting & Exhibition - Palais des congrès de Montréal, Montreal, Canada|
Duration: 11 May 2019 → 16 May 2019
|Conference||ISMRM 27th Annual Meeting & Exhibition|
|Period||11/05/19 → 16/05/19|