An optimised protocol for dynamic oxygen enhanced imaging of brain tumours

William Lloyd, Erjon Agushi, Daniel Lewis, David Coope, Alan Jackson, Geoff JM Parker

Research output: Contribution to conferencePosterpeer-review


Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method’s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.
Original languageEnglish
Publication statusPublished - 11 May 2019
EventISMRM 27th Annual Meeting & Exhibition - Palais des congrès de Montréal, Montreal, Canada
Duration: 11 May 201916 May 2019


ConferenceISMRM 27th Annual Meeting & Exhibition


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