An optimised protocol for dynamic oxygen enhanced imaging of brain tumours

William Lloyd; Erjon Agushi; Daniel Lewis; David Coope; Alan Jackson; Geoff JM Parker

An optimised protocol for dynamic oxygen enhanced imaging of brain tumours

William Lloyd
, Erjon Agushi
, Daniel Lewis
, David Coope
, Alan Jackson
, Geoff JM Parker

Research output: Contribution to conference › Poster › peer-review

Abstract

Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method’s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.

Original language	English
Publication status	Published - 11 May 2019
Event	ISMRM 27th Annual Meeting & Exhibition - Palais des congrès de Montréal, Montreal, Canada Duration: 11 May 2019 → 16 May 2019

Conference

Conference	ISMRM 27th Annual Meeting & Exhibition
Country/Territory	Canada
City	Montreal
Period	11/05/19 → 16/05/19

Cite this

@conference{d32a1b11b14d447ca43cbb19aa3c8351,

title = "An optimised protocol for dynamic oxygen enhanced imaging of brain tumours",

abstract = "Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method{\textquoteright}s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.",

author = "William Lloyd and Erjon Agushi and Daniel Lewis and David Coope and Alan Jackson and Parker, \{Geoff JM\}",

year = "2019",

month = may,

day = "11",

language = "English",

note = "ISMRM 27th Annual Meeting \& Exhibition ; Conference date: 11-05-2019 Through 16-05-2019",

}

TY - CONF

T1 - An optimised protocol for dynamic oxygen enhanced imaging of brain tumours

AU - Lloyd, William

AU - Agushi, Erjon

AU - Lewis, Daniel

AU - Coope, David

AU - Jackson, Alan

AU - Parker, Geoff JM

PY - 2019/5/11

Y1 - 2019/5/11

N2 - Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method’s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.

AB - Hypoxia is an important factor in tumour resistance and regression. The use of oxygen as an MR contrast agent is gaining interest but the technique has been hampered by relatively low contrast, noisy data. Here we present an optimised protocol for dynamic oxygen-enhanced MRI (dOE-MRI) of brain tumours. We present data from healthy normal volunteers that demonstrate the method’s capability of producing reliable oxygen-induced signal change and data from glioblastoma (GBM) patients demonstrating tumour sub-division specific changes, showing the potential of this method for mapping tumour hypoxia.

M3 - Poster

T2 - ISMRM 27th Annual Meeting & Exhibition

Y2 - 11 May 2019 through 16 May 2019

ER -

An optimised protocol for dynamic oxygen enhanced imaging of brain tumours

Abstract

Conference

Fingerprint

Cite this