An orphan PRD class hemeobox gene expressed in mouse brain and limb development

Tokiharu Takahashi, Peter W H Holland, Martin J. Cohn, Kiyoshi Shimizu, Mineo Kurokawa, Hisamaru Hirai

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We report the cDNA sequence and expression of a mouse homeobox gene, Dmbx1, from the PRD class and comparison to its human orthologue. The gene defines a new homeobox gene family, Dmbx, phylogenetically distinct from the Ptx, Alx, Prx Otx, Gsc, Otp and Pax gene families. The Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development. Unusually for homeobox genes, there is no orthologue in the Drosophila or Caenorhabditis genomes; we argue this reflects secondary loss.
    Original languageEnglish
    Pages (from-to)293-297
    Number of pages4
    JournalDevelopment Genes and Evolution
    Volume212
    Issue number6
    DOIs
    Publication statusPublished - 2002

    Keywords

    • Brain development
    • Homeobox
    • K50 homeodomain
    • Limb development
    • Paired

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